MS-RIDD paves the way toward routine double bond localization in mass spectrometry-based lipidomics

Leonida Marion Lamp; Jürgen Hartler

doi:10.1038/s42004-022-00805-1

MS-RIDD paves the way toward routine double bond localization in mass spectrometry-based lipidomics

Commun Chem. 2022 Dec 29;5(1):181. doi: 10.1038/s42004-022-00805-1.

Authors

Leonida Marion Lamp¹, Jürgen Hartler^{2

3}

Affiliations

¹ Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria.
² Institute of Pharmaceutical Sciences, University of Graz, Graz, Austria. juergen.hartler@uni-graz.at.
³ Field of Excellence BioHealth, University of Graz, Graz, Austria. juergen.hartler@uni-graz.at.

Abstract

Pinpointing double bond (C=C) positions in native lipid extracts is beyond the capabilities of standard mass spectrometry-based approaches. This article highlights a novel untargeted workflow supported by the open-source software MS-RIDD, that allows for semi-automated annotation of C=C locations with high confidence.