Role of Interleukin-22 in ulcerative colitis

Nan Zhao; Chuanguo Liu; Ning Li; Shuang Zhou; Yuting Guo; Shihua Yang; Huimin Liu

doi:10.1016/j.biopha.2023.114273

Role of Interleukin-22 in ulcerative colitis

Biomed Pharmacother. 2023 Mar:159:114273. doi: 10.1016/j.biopha.2023.114273. Epub 2023 Jan 23.

Authors

Nan Zhao¹, Chuanguo Liu², Ning Li³, Shuang Zhou⁴, Yuting Guo⁵, Shihua Yang⁶, Huimin Liu⁷

Affiliations

¹ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address: 2020110093@sdutcm.edu.cn.
² Experimental Center, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address: 60011973@sdutcm.edu.cn.
³ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address: 60020093@sdutcm.edu.cn.
⁴ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address: 2021110104@sdutcm.edu.cn.
⁵ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address: 2020110101@sdutcm.edu.cn.
⁶ Department of Oncology, The Fifth People's Hospital of Jinan, Jinan 250022, PR China. Electronic address: yangsh3009@163.com.
⁷ College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250355, PR China. Electronic address: 60020076@sdutcm.edu.cn.

PMID: 36696801
DOI: 10.1016/j.biopha.2023.114273

Abstract

Ulcerative Colitis (UC) is a chronic disease, in the progression of which an immune overreaction may play an important role. IL-22 is a member of the IL-10 superfamily of cytokines and is pleiotropic in immune regulation and inflammatory responses. IL-22 can produce protective effects, promote wound healing and tissue regeneration, while it can also induce inflammatory reactions when it is chronically overexpressed. Extensive literatures reported that IL-22 played an essential role in the pathogenic development of UC. IL-22 participates in the whole disease process of UC involving signaling pathways, gene expression regulation, and intestinal flora imbalance, making IL-22 a possible candidate for the treatment of UC. In this paper, the latest knowledge to further elucidate the role of IL-22 in UC was summarized and analyzed.

Keywords: IL-22; IL-22BP; STAT3; Ulcerative Colitis.

Publication types

Review

MeSH terms

Colitis, Ulcerative* / pathology
Cytokines / metabolism
Humans
Inflammation
Interleukin-22
Interleukins / metabolism

Substances

Interleukins
Cytokines