SGK1 inhibition induces fetal hemoglobin expression and delays polymerization in sickle erythroid cells

Blood Adv. 2023 Jun 13;7(11):2317-2323. doi: 10.1182/bloodadvances.2022008710.

Authors

Yannis Hara^{1

2}, Viktor T Lemgart³, Nis Halland⁴, Kiana Mahdaviani⁵, Jean-Antoine Ribeil⁵, Samuel Lessard^{2

6}, Alexandra Hicks^{1

2}, David R Light²

Affiliations

¹ Immunology and Inflammation, Sanofi, Cambridge, MA.
² Rare Blood Disorders, Sanofi, Waltham, MA.
³ Tidal Therapeutics, Cambridge, MA.
⁴ Integrated Drug Discovery, Sanofi, Frankfurt, Germany.
⁵ Sickle Cell Center of Excellence, Boston University Medical Center, Boston, MA.
⁶ Precision Medicine and Computational Biology, Sanofi, Framingham, MA.

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anemia, Sickle Cell* / metabolism
Erythrocytes, Abnormal / metabolism
Erythroid Cells / metabolism
Fetal Hemoglobin* / genetics
Fetal Hemoglobin* / metabolism
Humans
Polymerization

Substances

Fetal Hemoglobin