Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022

Béatrice Berçot; François Caméléna; Manel Mérimèche; Susanne Jacobsson; Ghalia Sbaa; Mary Mainardis; Cyrille Valin; Jean-Michel Molina; Cécile Bébéar; Emilie Chazelle; Florence Lot; Daniel Golparian; Magnus Unemo

doi:10.2807/1560-7917.ES.2022.27.50.2200899

Ceftriaxone-resistant, multidrug-resistant Neisseria gonorrhoeae with a novel mosaic penA-237.001 gene, France, June 2022

Euro Surveill. 2022 Dec;27(50):2200899. doi: 10.2807/1560-7917.ES.2022.27.50.2200899.

Authors

Béatrice Berçot^{1

2

3}, François Caméléna^{1

2

3}, Manel Mérimèche^{1

2

3}, Susanne Jacobsson⁴, Ghalia Sbaa^{1

2}, Mary Mainardis^{1

2}, Cyrille Valin⁵, Jean-Michel Molina^{6

7}, Cécile Bébéar⁸, Emilie Chazelle⁹, Florence Lot⁹, Daniel Golparian⁴, Magnus Unemo^{10

4}

Affiliations

¹ French National Reference Centre for bacterial STIs, Associated Laboratory for Gonococci, Paris, France.
² APHP, Infectious Agents Department, Saint Louis Hospital, Paris, France.
³ Université Paris Cité, INSERM, IAME, Paris, France.
⁴ WHO Collaborating Centre for Gonorrhoea and Other STIs, National Reference Laboratory for STIs, Department of Laboratory Medicine, Faculty of Medicine and Health, Ӧrebro University, Ӧrebro, Sweden.
⁵ Laboratoire Anse, Biogroup, Lyon, France.
⁶ Université Paris Cité, UMR S976, INSERM, Paris, France.
⁷ AP-HP, Hôpital Saint-Louis, Lariboisière, Département de Maladies Infectieuses et Tropicales, Paris, France.
⁸ University of Bordeaux, USC EA 3671, Mycoplasmal and Chlamydial Infections in Humans, Bordeaux University Hospital, French National Reference Centre for Bacterial STIs, Bordeaux, France.
⁹ Santé Publique France, French National Public Health Agency, Saint-Maurice, France.
¹⁰ Institute for Global Health, University College London, London, United Kingdom.

PMID: 36695466
PMCID: PMC9808317
DOI: 10.2807/1560-7917.ES.2022.27.50.2200899

Abstract

We report a ceftriaxone-resistant, multidrug-resistant urogenital gonorrhoea case in a heterosexual woman in France, June 2022. The woman was successfully treated with azithromycin 2 g. She had unprotected sex with her regular partner, who developed urethritis following travel to Vietnam and Switzerland. Whole genome sequencing of the gonococcal isolate (F92) identified MLST ST1901, NG-STAR CC-199, and the novel mosaic penA-237.001, which caused ceftriaxone resistance. penA-237.001 is 98.7% identical to penA-60.001, reported in various ceftriaxone-resistant strains, including the internationally spreading FC428 clone.

Keywords: Neisseria gonorrhoeae; antimicrobial resistance; ceftriaxone; multidrug-resistant N. gonorrhoeae (MDR-NG); travel.

MeSH terms

Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / therapeutic use
Ceftriaxone* / pharmacology
Ceftriaxone* / therapeutic use
Drug Resistance, Bacterial / genetics
Female
Gonorrhea* / diagnosis
Gonorrhea* / drug therapy
Humans
Microbial Sensitivity Tests
Multilocus Sequence Typing
Neisseria gonorrhoeae

Substances

Ceftriaxone
Anti-Bacterial Agents