High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study

Abstract

Objectives: To investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.

Study design: The Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.

Setting: The area was set in the rural area of Dongguan, Southern China.

Participants: Adult rural population aged 40 or older.

Methods: Participants underwent physical, haematological and ophthalmic examinations.

Primary and secondary outcome measures: The frequency and risk factors of pterygium.

Results: A total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. The prevalence of pterygium was 17.3% after adjusting the sex and age distribution, 22.0% in participants with hypercholesterolaemia (total cholesterol ≥6.22 mmol/L (240 mg/dL)) and 21.8% in those with low-density lipoprotein-cholesterol (LDL-C) ≥4.14 mmol/L (160 mg/dL), respectively. After adjusting for multiple confounding factors, higher level of high-density lipoprotein-cholesterol (HDL-C) (OR: 1.23, 95% CI: 1.06 to 1.41) and LDL-C (OR: 1.13, 95% CI: 1.06 to 1.20) were positively associated with the risk of pterygium. The ORs for HDL-C or LDL-C with pterygium were significantly greater in participants aged 40-49 years than those aged 50 years or above (P for interaction <0.001). Furthermore, increased HDL-C showed greater association with pterygium in normal body mass index (BMI) group compared with overweight group (P for interaction=0.002).

Conclusion: Increased HDL-C and LDL-C are risk factors of pterygium, especially in people <50 years or those with normal BMI level. Strict control of HDL-C and LDL-C may be a new prevention method in reducing the risk of pterygium.

Keywords: high-density lipoprotein-cholesterol; low-density lipoprotein-cholesterol; population-based study; pterygium; risk factor.