Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis

Tian-Ying Lan; Rong-Liang Dun; Dong-Sheng Yao; Feng Wu; Yi-Ling Qian; Yuan Zhou; Tian-Tian Zhan; Ming-Hai Shao; Jian-Dong Gao; Chen Wang

doi:10.3389/fnut.2022.1064507

Effects of resveratrol on renal ischemia-reperfusion injury: A systematic review and meta-analysis

Front Nutr. 2023 Jan 4:9:1064507. doi: 10.3389/fnut.2022.1064507. eCollection 2022.

Authors

Tian-Ying Lan^{1

2

3

4}, Rong-Liang Dun⁵, Dong-Sheng Yao^{1

2

3

4}, Feng Wu^{1

2

3

4}, Yi-Ling Qian^{1

2

3

4}, Yuan Zhou^{1

2

3

4}, Tian-Tian Zhan^{1

2

3

4}, Ming-Hai Shao^{1

2

3

4}, Jian-Dong Gao^{1

2

3

4}, Chen Wang^{1

2

3

4}

Affiliations

¹ Nephrology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
² TCM Institute of Kidney Disease, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
³ Key Laboratory of Liver and Kidney Diseases, Shanghai University of Traditional Chinese Medicine, Ministry of Education, Shanghai, China.
⁴ Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
⁵ Urology Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China.

Abstract

Renal ischemia-reperfusion (I/R) injury may lead to acute kidney injury, which is characterized by high morbidity and mortality rates. Resveratrol (RSV) can be extracted from Chinese herbs, and multiple animal experiments have demonstrated its potential for renal protection. This systematic review evaluates the protective effect of RSV against renal I/R injury in animal models. The PubMed, Embase, Web of Science, and Science Direct databases were searched for animal experiments related to RSV in renal I/R injury from their establishment to June 2022. In total, 19 studies were included with 249 animals (129 treated with RSV and 120 as controls). The pooled analysis revealed that RSV administration significantly decreased serum creatinine (SCr) levels (16 studies, n = 243, WMD = -58.13, 95% CI = -79.26 to -37.00, p < 0.00001) and blood urea nitrogen (BUN) levels (12 studies, n = 163, WMD = -34.37, 95% CI = -46.70 to -22.03, p < 0.00001) in the renal I/R injury model. The level of malondialdehyde (MDA), an oxidative stress index, was alleviated [7 studies, n = 106, standardized mean difference (SMD) = -6.05, 95% CI = -8.90 to -3.21, p < 0.0001] and antioxidant enzymes such as glutathione (GSH) (7 studies, n = 115, SMD = 9.25, 95% CI = 5.51-13.00, p < 0.00001) and catalase (CAT) (4 studies, n = 59, SMD = 8.69, 95% CI = 4.35-13.03, p < 0.0001) were increased after treatment of RSV. The subgroup analysis suggested that 5-10 mg/kg of RSV optimally protects against renal I/R injury as both the BUN and SCr levels were significantly decreased at this dosage. The protective effects of RSV against renal I/R injury might be attributed to multiple mechanisms, such as inhibiting oxidative stress, apoptosis, inflammation, fibrillation, and promoting autophagy. For a deeper understanding of the protective effects of RSV, experimental studies on animal models and large randomized controlled trials in humans are needed.

Keywords: meta-analysis; oxidative stress; reactive oxygen species; renal ischemia-reperfusion injury; resveratrol; systematic review.

Publication types

Systematic Review