Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

Hongliang Wu; Sihang Zheng; Qun He; Yan Li

doi:10.2147/IJGM.S380834

Recent Advances of Circular RNAs as Biomarkers for Osteosarcoma

Int J Gen Med. 2023 Jan 15:16:173-183. doi: 10.2147/IJGM.S380834. eCollection 2023.

Authors

Hongliang Wu^{1

2

3}, Sihang Zheng⁴, Qun He⁵, Yan Li³

Affiliations

¹ Department of Orthopedics, Fuzhou Second Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, People's Republic of China.
² Department of Orthopedics, Fuzhou Second Hospital, Fuzhou, People's Republic of China.
³ Department of Orthopedics, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
⁴ Department of Neurology, Shengjing Hospital of China Medical University, Shenyang, People's Republic of China.
⁵ Department of Bioinformatics, School of Life Sciences, China Medical University, Shenyang, People's Republic of China.

Abstract

Osteosarcoma is the most common primary malignant bone tumor in young adult, which is prone to early metastasis and poor prognosis. The current treatment methods need to be improved. Circular RNA is a covalently blocked circular, non-coding RNA that plays an essential role in the occurrence, development, clinical diagnosis, and treatment of various diseases. Recently, an increasing number of circRNAs have been identified in osteosarcoma. Understanding its role in osteosarcoma is conducive to the early detection, diagnosis, and treatment of osteosarcoma. In this paper, we reviewed the mechanism of action of circular RNA in the occurrence and development of osteosarcoma and its clinical application in recent years.

Keywords: biomarker; circular RNA; exosome; osteosarcoma.

Publication types

Review

Grants and funding

This study was supported by the National Natural Science Foundation of China(81272946); The College Students’ Innovation Project of China Medical University; Fujian Provincial Clinical Medical Research Center for First Aid and Rehabilitation in Orthopaedic Trauma(2020Y2014).