2(1 H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations

Gerard Riesco-Llach; Marta Planas; Lidia Feliu; John A Joule

doi:10.1039/d2ra07227k

2(1 H)-Pyrazinones from acyclic building blocks: methods of synthesis and further derivatizations

RSC Adv. 2023 Jan 4;13(2):1162-1184. doi: 10.1039/d2ra07227k. eCollection 2023 Jan 3.

Authors

Gerard Riesco-Llach¹, Marta Planas¹, Lidia Feliu¹, John A Joule²

Affiliations

¹ LIPPSO, Department of Chemistry, Universitat de Girona Maria Aurèlia Capmany 69 Girona 17003 Spain lidia.feliu@udg.edu marta.planas@udg.edu.
² The School of Chemistry, The University of Manchester Manchester M13 9PL UK John.Joule@manchester.ac.uk.

Abstract

Pyrazinones (2(1H)-pyrazinones) are found as components of a range of natural substances and are involved in the preparation of a great number of bioactive molecules. Synthesis of such compounds, and analogues, requires knowledge of the heterocyclic properties of pyrazinones and, in particular, methods for their ring construction. This review deals with the strategies that have been developed for the synthesis of pyrazinones from acyclic precursors, especially α-amino acid-derived units, from the first examples in 1905 up to the most recent in 2021.

Publication types

Review