A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study

Chenjing Wang; Xin Jiang; Xiaolei Zhang; Yi Xu; Li Li; Xin Li; Shanglong Wang; Ping Shi; Xiaomeng Gao; Zimin Liu; W Dennis Clark; Yu Cao

doi:10.1016/j.heliyon.2023.e12829

A novel solvent-free co-grinding preparation improves curcumin bioavailability in healthy volunteers: A single-center crossover study

Heliyon. 2023 Jan 5;9(1):e12829. doi: 10.1016/j.heliyon.2023.e12829. eCollection 2023 Jan.

Authors

Chenjing Wang¹, Xin Jiang¹, Xiaolei Zhang¹, Yi Xu¹, Li Li², Xin Li², Shanglong Wang², Ping Shi¹, Xiaomeng Gao¹, Zimin Liu^{2

3}, W Dennis Clark³, Yu Cao¹

Affiliations

¹ Phase I Clinical Research Center, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Shinan District, Qingdao City, Shandong Province 266003, China.
² Chenland Research Institute, 333 Songling Road, Laoshan District, Qingdao City, Shandong Province 266104, China.
³ Chenland Nutritionals, Inc., 3 Park Plaza, Suite 0410, Irvine, CA 92614, USA.

Abstract

Curcumin, from the rhizome of turmeric (Curcuma longa L.), has a wide variety of biological activities. Unfortunately, its poor water-solubility greatly limits its bioavailability. The purpose of this study was to evaluate CUMINUP60®, a novel preparation utilizing a solvent-free, co-grinding method designed to improve curcumin's bioavailability. We performed a single-center crossover experiment to compare the new product with standard 95% curcumin in the blood plasma of twelve healthy adults (10 males, 2 females). Total bioavailability of curcumin and its sulfate and glucuronide conjugates from the test product, measured by their areas under the curve over 12 h (AUC_0-T), showed a combined increase of 178-fold over standard curcumin and its conjugates from the reference product. The new product represents a significant improvement for providing greater bioavailability of curcumin, as compared with several other branded preparations. It therefore has broad applications for preparing curcumin as a more effective health ingredient in functional foods, beverages, and nutraceuticals.

Keywords: CUMINUP60®; Curcumin; Oral bioavailability; Pharmacokinetics.