The influence of timing of oocytes retrieval and embryo transfer on the IVF-ET outcomes in patients having bilateral salpingectomy due to bilateral hydrosalpinx

He Yilei; Yang Shuo; Ma Caihong; Yang Yan; Song Xueling; Zhang Jiajia; Liu Ping; Li Rong; Qiao Jie

doi:10.3389/fsurg.2022.1076889

The influence of timing of oocytes retrieval and embryo transfer on the IVF-ET outcomes in patients having bilateral salpingectomy due to bilateral hydrosalpinx

Front Surg. 2023 Jan 5:9:1076889. doi: 10.3389/fsurg.2022.1076889. eCollection 2022.

Authors

He Yilei^{1

2

3

4}, Yang Shuo^{1

2

3

4}, Ma Caihong^{1

2

3

4}, Yang Yan^{1

2

3

4}, Song Xueling^{1

2

3

4}, Zhang Jiajia^{1

2

3

4}, Liu Ping^{1

2

3

4}, Li Rong^{1

2

3

4}, Qiao Jie^{1

2

3

4}

Affiliations

¹ Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
² National Clinical Research Center for Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
³ Key Laboratory of Assisted Reproduction, Ministry of Education, Peking University, Beijing, China.
⁴ Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology, Beijing, China.

Abstract

Objective: The objective of the study was to investigate whether the sequence of oocyte retrieval and salpingectomy for hydrosalpinx affects pregnancy outcomes of in vitro fertilization and embryo transfer (IVF-ET) patients.

Study design: There were 1,610 bilateral hydrosalpinx patients who underwent laparoscopy salpingectomy and IVF-ET/intracytoplasmic sperm injection (ICSI) from January 2009 to December 2018. They were divided into two groups: oocyte retrieval first group: 235 accepted oocyte retrieval before salpingectomy; operation first group: 1,375 accepted oocyte retrieval after salpingectomy. The basic information and pregnancy outcomes of the two groups were compared. The pregnancy outcomes and influencing factors were analyzed among patients at different starting times of frozen-thawed embryo transfer (FET) or oocyte retrieval after the salpingectomy.

Results: Patients in the oocyte retrieval first group had higher levels of basal follicle stimulating hormone and lower anti-Mullerian hormone levels (P < 0.05). There were no cases of pelvic infection or oocyte and embryo contamination after oocyte retrieval in the oocyte retrieval first group. In the frozen cycle, the clinical pregnancy and miscarriage rates of the oocyte retrieval first group were lower than those in the operation first group (P < 0.05), while the live birth rate was not significantly different (P > 0.05). The live birth rates of patients ≥35 years old in the operation first group and the oocyte retrieval first group were not significantly different (29.3% vs. 23.3%, P = 0.240). After adjusting for age and antral follicle count (AFC), oocyte retrieval 4-6 and 7-12 months after the operation had higher accumulated pregnancy rates [OR 1.439 (1.045-1.982), P = 0.026; OR 1.509 (1.055-2.158), P = 0.024] and higher accumulated live birth rates [OR 1.419 (1.018-1.977), P = 0.039; OR 1.544 (1.068-2.230), P = 0.021]. No significant difference was observed in the pregnancy outcomes of frozen embryo transfer at different times after salpingectomy (P > 0.05).

Conclusion: No contamination of the embryo or infection was observed in patients who underwent oocyte retrieval before the operation. The interval between the operation and frozen embryo transfer did not affect the pregnancy outcomes. After adjusting for age and AFC, patients who underwent oocyte retrieval 4-6 and 7-12 months after the operation had higher accumulated pregnancy rates and live birth rates.

Keywords: embryo transfer; in vitro fertilization; laparoscopy; pregnancy outcome; salpingectomy.