Preoperative Prediction of Sinonasal Inverted Papilloma-associated Squamous Cell Carcinoma (IP-SCC)

Marn Joon Park; Wonki Cho; Ji Heui Kim; Yoo-Sam Chung; Yong Ju Jang; Myeong Sang Yu

doi:10.1002/lary.30583

Preoperative Prediction of Sinonasal Inverted Papilloma-associated Squamous Cell Carcinoma (IP-SCC)

Laryngoscope. 2023 Oct;133(10):2502-2510. doi: 10.1002/lary.30583. Epub 2023 Jan 23.

Authors

Marn Joon Park^{1

2}, Wonki Cho¹, Ji Heui Kim¹, Yoo-Sam Chung¹, Yong Ju Jang¹, Myeong Sang Yu¹

Affiliations

¹ Department of Otorhinolaryngology-Head & Neck Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
² Department of Otorhinolaryngology-Head and Neck Surgery, Inha University Medical Center, Inha University School of Medicine, Incheon, South Korea.

PMID: 36683553
DOI: 10.1002/lary.30583

Abstract

Introduction: Sinonasal inverted papillomas (IP) can undergo transformation into IP-squamous cell carcinomas (IP-SCC). More aggressive treatment plan should be established when IP-SCC is suspected. Nevertheless, inaccuracy of the preoperative punch biopsy results to detect IP-SCC from IP raises the need for an additional strategy. The present study aimed to investigate significant clinicoradiological remarks associated with IP-SCC than IP.

Material and methods: Postoperative surgical specimens obtained from patients with confirmed IP or IP-SCC at a single tertiary medical center from 1997 to 2018 were retrospectively evaluated. Patients' demographic and clinical characteristics, preoperative in-office punch biopsy results, and preoperative computed tomography (CT) or magnetic resonance images were reviewed. Univariate and multivariate analyses were performed to assess the odds ratio (OR) associated with IP-SCC. The area under the curve (AUC) in the receiver Operating Characteristic (ROC) curve was calculated in the prediction model to discriminate IP-SCC from IP.

Results: The study included 44 IP-SCC and 301 patients with IP. The diagnostic sensitivity of in-office punch biopsy to detect IP-SCC was 70.7%. Multivariate analysis showed that factors significantly associated with IP-SCC included tobacco smoking >10PY (adjusted-OR [aOR]: 4.1), epistaxis (aOR: 3.4), facial pain (aOR: 4.2), bony destruction (aOR: 37.6), bony remodeling (aOR: 36.3), and invasion of adjacent structures (aOR: 31.6) (all p < 0.05). Combining all significantly related clinicoradiological features, the ability to discriminate IP-SCC from IP reached an AUC of 0.974.

Conclusion: IP patients with a history of tobacco smoking, facial pain, epistaxis, and bony destruction, remodeling, or invasion of an adjacent structure on preoperative images may be at higher risk for IP-SCC.

Level of evidence: 3 Laryngoscope, 133:2502-2510, 2023.

Keywords: computed tomography; inverted papilloma; sinonasal tumors; squamous cell carcinoma.

MeSH terms

Carcinoma, Squamous Cell* / pathology
Epistaxis / complications
Facial Pain
Humans
Nose Neoplasms* / pathology
Papilloma, Inverted* / surgery
Paranasal Sinus Neoplasms* / complications
Paranasal Sinus Neoplasms* / diagnostic imaging
Paranasal Sinus Neoplasms* / surgery
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck / complications