Interrelation of T cell cytokines and autoantibodies in systemic lupus erythematosus: A cross-sectional study

Clin Immunol. 2023 Feb:247:109239. doi: 10.1016/j.clim.2023.109239. Epub 2023 Jan 20.

Abstract

T-helper cytokines interferon gamma (IFNɣ), interleukin 17 (IL-17) and IL-10 impact systemic lupus erythematosus (SLE) directly and indirectly via modulation of autoAb production. We determined the separate and combined effects on clinical manifestations of SLE (N = 62). IFNɣ, IL-17 but not IL-10 were significantly elevated in patients with SLE. IFNɣ positively correlated with anti-DNA and anti-SSA. IL-17 positively correlated with anti-SSA and was significantly higher in patients with discoid rash and class V LN. IL-10 did not correlate with circulating autoantibodies but was significantly elevated in patients with LN. Patients with LN had elevated plasma levels of anti-DNA and anti-Sm/ribonuclear protein (RNP). Anti-Sm/RNP levels were decreased in patients with acute mucocutaneous manifestations, including photosensitivity and/or malar rash. The study provides critical insights into pathological mechanisms of LN, which could help guide future diagnoses and therapies.

Keywords: Interferon gamma; Interleukin 10; Interleukin 17; Lupus nephritis; Systemic lupus erythematosus.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies, Antinuclear
  • Autoantibodies
  • Cross-Sectional Studies
  • Cytokines
  • Humans
  • Interferon-gamma
  • Interleukin-17
  • Lupus Erythematosus, Systemic*
  • Lupus Nephritis*
  • T-Lymphocytes

Substances

  • Cytokines
  • Interleukin-17
  • Autoantibodies
  • Interferon-gamma
  • Antibodies, Antinuclear

Supplementary concepts

  • malar rash