[Cytomegalovirus reactivation in patients with immune-mediated gastritis]

Abstract

Introduction: Reactivation of cytomegalovirus can complicate the evolution of patients with gastritis induced by immune checkpoint inhibitors.

Methods: The experience in our center is described and a review of the literature is performed.

Results: A case of severe gastritis induced by treatment with a programmed cell death receptor-1 (anti-PD1) inhibitor, associated with reactivation of cytomegalovirus (CMV) is described. In the systematic review, we identified 5 cases of immune-related gastritis associated with CMV reactivation. Ganciclovir treatment contributed to clinical improvement in most patients.

Conclusion: The early identification of a CMV infection in patients with severe or refractory immune-related gastritis will allow the initiation of targeted treatment, and may avoid increasing immunosuppressive therapy.

Keywords: Citomegalovirus; Cytomegalovirus; Gastritis; Immune checkpoint inhibitor; Immunotherapy; Inhibidor del punto de control inmunitario; Inmunoterapia.