Combined effect of microplastic, salinomycin and heating on Unio tumidus

Viktoria Martyniuk; Vira Khoma; Tetiana Matskiv; Kateryna Yunko; Lesya Gnatyshyna; Oksana Stoliar; Caterina Faggio

doi:10.1016/j.etap.2023.104068

Combined effect of microplastic, salinomycin and heating on Unio tumidus

Environ Toxicol Pharmacol. 2023 Mar:98:104068. doi: 10.1016/j.etap.2023.104068. Epub 2023 Jan 19.

Authors

Viktoria Martyniuk¹, Vira Khoma², Tetiana Matskiv³, Kateryna Yunko⁴, Lesya Gnatyshyna⁵, Oksana Stoliar⁶, Caterina Faggio⁷

Affiliations

¹ Ternopil Volodymyr Hnatiuk National Pedagogical University, M. Kryvonosa Str. 2, 46027 Ternopil, Ukraine. Electronic address: martynjyk23@ukr.net.
² Ternopil Volodymyr Hnatiuk National Pedagogical University, M. Kryvonosa Str. 2, 46027 Ternopil, Ukraine. Electronic address: khomav@tnpu.edu.ua.
³ Ternopil Volodymyr Hnatiuk National Pedagogical University, M. Kryvonosa Str. 2, 46027 Ternopil, Ukraine; I. Ya. Horbachevsky Ternopil National Medical University, Maidan Voli 1, 46001 Ternopil, Ukraine. Electronic address: mackiw@tdmu.edu.ua.
⁴ Ternopil Volodymyr Hnatiuk National Pedagogical University, M. Kryvonosa Str. 2, 46027 Ternopil, Ukraine. Electronic address: yunko@chem-bio.com.ua.
⁵ Ternopil Volodymyr Hnatiuk National Pedagogical University, M. Kryvonosa Str. 2, 46027 Ternopil, Ukraine; I. Ya. Horbachevsky Ternopil National Medical University, Maidan Voli 1, 46001 Ternopil, Ukraine. Electronic address: gnatyshynall@tdmu.edu.ua.
⁶ Ternopil Volodymyr Hnatiuk National Pedagogical University, M. Kryvonosa Str. 2, 46027 Ternopil, Ukraine. Electronic address: Oksana.Stolyar@tnpu.edu.ua.
⁷ Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno d'Alcontres, 31, 98166 S Agata -Messina, Italy. Electronic address: cfaggio@unime.it.

PMID: 36680920
DOI: 10.1016/j.etap.2023.104068

Abstract

Microplastic (MP) and heating (T) suspected to modulate biological effects of aquatic contaminants. Salinomycin (Sal) is veterinary antibiotic and anticancer agent. The goal of this study was to examine the multistress effect of MP, Sal and T on the bioindicator bivalve mollusc. The Unio tumidus were treated with MP (1 mg L^-1), Sal (0.6 µg L^-1), their combination under 18° C (Mix) and 25° C (MixT) for 14 days. The digestive glands were analyzed. MP and Sal did not cause changes of Mn- and Cu,Zn-SOD, lipid peroxidation and Cyp-450-depended EROD levels, whereas catalase, GST and protein carbonyls (Sal-group) increased compared to control. In the Mix-group, enzymes, particularly EROD and GST (by 34% and 115% respectively) were up-regulated. However, in the MixT-group, they were corresponding to control or lesser (EROD, catalase). Our findings emphasize the need to take into account multistress interactions in the MP environmental risk assessment.

Keywords: Biotransformation; Microplastic; Mussel; Oxidative stress; Pharmaceutical; Toxicity.

MeSH terms

Animals
Catalase / metabolism
Cytochrome P-450 CYP1A1 / metabolism
Heating
Microplastics
Plastics
Unio* / metabolism
Water Pollutants, Chemical* / analysis

Substances

Catalase
Microplastics
Plastics
salinomycin
Cytochrome P-450 CYP1A1
Water Pollutants, Chemical