Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Eun-Jin Cheon; Alie G Male; Bingchen Gao; Bhim M Adhikari; Jesse T Edmond; Stephanie M Hare; Aysenil Belger; Steven G Potkin; Juan R Bustillo; Daniel H Mathalon; Judith M Ford; Kelvin O Lim; Bryon A Mueller; Adrian Preda; Daniel O'Leary; Gregory P Strauss; Anthony O Ahmed; Paul M Thompson; Neda Jahanshad; Peter Kochunov; Vince D Calhoun; Jessica A Turner; Theo G M van Erp

doi:10.1016/j.pscychresns.2023.111597

Five negative symptom domains are differentially associated with resting state amplitude of low frequency fluctuations in Schizophrenia

Psychiatry Res Neuroimaging. 2023 Mar:329:111597. doi: 10.1016/j.pscychresns.2023.111597. Epub 2023 Jan 16.

Authors

Eun-Jin Cheon¹, Alie G Male², Bingchen Gao², Bhim M Adhikari³, Jesse T Edmond⁴, Stephanie M Hare³, Aysenil Belger⁵, Steven G Potkin⁶, Juan R Bustillo⁷, Daniel H Mathalon⁸, Judith M Ford⁸, Kelvin O Lim⁹, Bryon A Mueller⁹, Adrian Preda⁶, Daniel O'Leary¹⁰, Gregory P Strauss¹¹, Anthony O Ahmed¹², Paul M Thompson¹³, Neda Jahanshad¹³, Peter Kochunov³, Vince D Calhoun⁴, Jessica A Turner¹⁴, Theo G M van Erp¹⁵

Affiliations

¹ Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Department of Psychiatry, Yeungnam University College of Medicine, Daegu, South Korea.
² Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
³ Maryland Psychiatric Research Center, Department of Psychiatry, University of Maryland School of Medicine, United States.
⁴ Center for Translational Research in Neuroimaging and Data Science (TReNDS), GSU/GATech/Emory, Atlanta, GA, United States.
⁵ Department of Psychiatry, University of North Carolina, Chapel Hill, United States.
⁶ Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States.
⁷ Departments of Psychiatry & Neuroscience, University of New Mexico, Albuquerque, NM, United States.
⁸ Department of Psychiatry, Weill Institute for Neurosciences, University of California, San Francisco, CA, United States; Veterans Affairs San Francisco Healthcare System, San Francisco, CA, United States.
⁹ Department of Psychiatry and Behavioral Sciences, University of Minnesota, Minneapolis, MN, United States.
¹⁰ Department of Psychiatry, University of Iowa, IA, United States.
¹¹ Department of Psychology, University of Georgia, Athens, GA, United States.
¹² Department of Psychiatry, Weill Cornell Medicine, White Plains, NY, United States.
¹³ Imaging Genetics Center, University of Southern California, Marina del Rey, CA, United States.
¹⁴ Department of Psychiatry, Ohio State University, OH, United States.
¹⁵ Clinical Translational Neuroscience Laboratory, Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine, CA, United States; Center for the Neurobiology of Learning and Memory, University of California Irvine, Irvine, CA, United States. Electronic address: tvanerp@uci.edu.

PMID: 36680843
DOI: 10.1016/j.pscychresns.2023.111597

Abstract

This study examined associations between resting-state amplitude of low frequency fluctuations (ALFF) and negative symptoms represented by total scores, second-order dimension (motivation and pleasure, expressivity), and first-order domain (anhedonia, avolition, asociality, alogia, blunted affect) factor scores in schizophrenia (n = 57). Total negative symptom scores showed positive associations with ALFF in temporal and frontal brain regions. Negative symptom domain scores showed predominantly stronger associations with regional ALFF compared to total scores, suggesting domain scores may better map to neural signatures than total scores. Improving our understanding of the neuropathology underlying negative symptoms may aid in addressing this unmet therapeutic need in schizophrenia.

Keywords: ALFF; Avolition; Negative symptoms.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Anhedonia
Brain / diagnostic imaging
Humans
Mood Disorders
Motivation
Schizophrenia* / diagnostic imaging

Abstract

Publication types

MeSH terms

Grants and funding