Biocompatibility and Antimicrobial Activity of Electrospun Fibrous Materials Based on PHB and Modified with Hemin

Polina M Tyubaeva; Ivetta A Varyan; Elena D Nikolskaya; Mariia R Mollaeva; Nikita G Yabbarov; Maria B Sokol; Margarita V Chirkina; Anatoly A Popov

doi:10.3390/nano13020236

Biocompatibility and Antimicrobial Activity of Electrospun Fibrous Materials Based on PHB and Modified with Hemin

Nanomaterials (Basel). 2023 Jan 5;13(2):236. doi: 10.3390/nano13020236.

Authors

Polina M Tyubaeva^{1

2}, Ivetta A Varyan^{1

2}, Elena D Nikolskaya¹, Mariia R Mollaeva¹, Nikita G Yabbarov¹, Maria B Sokol¹, Margarita V Chirkina¹, Anatoly A Popov^{1

2}

Affiliations

¹ Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, 4 Kosygina Street, 119334 Moscow, Russia.
² Academic Department of Innovational Materials and Technologies Chemistry, Plekhanov Russian University of Economics, 36 Stremyanny Per., 117997 Moscow, Russia.

Abstract

The effect of the hemin (Hmi) on the structure and properties of nanocomposite electrospun materials based on poly-3-hydroxybutyrate (PHB) is discussed in the article. The additive significantly affected the morphology of fibers allowed to produce more elastic material and provided high antimicrobial activity. The article considers also the impact of the hemin on the biocompatibility of the nonwoven material based on PHB and the prospects for wound healing.

Keywords: antimicrobial activity; biocompatibility; electrospun fibrous materials; hemin; poly-3-hydroxybutyrate.

Grants and funding

22-73-00038/Russian Science Foundation