A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies

Hui Ming; Kunpeng Zhang; Shengbo Ge; Yang Shi; Chunan Du; Xuqiang Guo; Libo Zhang

doi:10.3390/nano13020224

A Mini Review of S-Nitrosoglutathione Loaded Nano/Micro-Formulation Strategies

Nanomaterials (Basel). 2023 Jan 4;13(2):224. doi: 10.3390/nano13020224.

Authors

Hui Ming¹, Kunpeng Zhang¹, Shengbo Ge², Yang Shi², Chunan Du³, Xuqiang Guo¹, Libo Zhang¹

Affiliations

¹ State Key Laboratory of Heavy Oil Processing, College of Engineering, China University of Petroleum-Beijing at Karamay, Karamay 834000, China.
² Jiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources, International Innovation Center for Forest Chemicals and Materials, College of Materials Science and Engineering, Nanjing Forestry University, Nanjing 210037, China.
³ Faculty of Chemical Engineering, Shandong Institute of Petroleum and Chemical Technology, Dongying 257000, China.

Abstract

As a potential therapeutic agent, the clinical application of S-nitrosoglutathione (GSNO) is limited because of its instability. Therefore, different formulations have been developed to protect GSNO from degradation, delivery and the release of GSNO at a physiological concentration in the active position. Due to the high water-solubility and small molecular-size of GSNO, the biggest challenges in the encapsulation step are low encapsulation efficiency and burst release. This review summarizes the different nano/micro-formulation strategies of a GSNO related delivery system to provide references for subsequent researchers interested in GSNO encapsulation.

Keywords: S-nitrosoglutathione; encapsulation; formulation; strategies.

Publication types

Review

Abstract

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