In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance

Shun-Yi Jian; Chiu-Feng Lin; Tung-Lin Tsai; Pei-Hua Wang; Chung-Hwan Chen; Sung-Yen Lin; Chun-Chieh Tseng

doi:10.3390/ijms24021602

In Vivo Degradation Behavior of Magnesium Alloy for Bone Implants with Improving Biological Activity, Mechanical Properties, and Corrosion Resistance

Int J Mol Sci. 2023 Jan 13;24(2):1602. doi: 10.3390/ijms24021602.

Authors

Shun-Yi Jian^{1

2}, Chiu-Feng Lin³, Tung-Lin Tsai⁴, Pei-Hua Wang⁴, Chung-Hwan Chen^{5

6

7

8

9

10

11}, Sung-Yen Lin^{5

6

7

9

12}, Chun-Chieh Tseng⁴

Affiliations

¹ Department of Material Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
² Center for Plasma and Thin Film Technologies, Ming Chi University of Technology, New Taipei 24301, Taiwan.
³ Department of CEO, Metal Industries Research & Development Centre, Kaohsiung 802, Taiwan.
⁴ Combination Medical Device Technology Division, Medical Devices R&D Service Department, Metal Industries Research & Development Centre, Kaohsiung 802, Taiwan.
⁵ Departments of Orthopedics, School of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁶ Orthopaedic Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁷ Regeneration Medicine and Cell Therapy Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁸ Musculoskeletal Regeneration Research Center, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
⁹ Department of Orthopedics, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung 80145, Taiwan.
¹⁰ Department of Healthcare Administration and Medical Informatics, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.
¹¹ Institute of Medical Science and Technology, National Sun Yat-Sen University, Kaohsiung 80424, Taiwan.
¹² Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80701, Taiwan.

Abstract

This study aimed to establish a surface modification technology for ZK60 magnesium alloy implants that can degrade uniformly over time and promote bone healing. It proposes a special micro-arc oxidation (MAO) treatment on ZK60 alloy that enables the composite electrolytes to create a coating with better corrosion resistance and solve the problems of uneven and excessive degradation. A magnesium alloy bone screw made in this way was able to promote the bone healing reaction after implantation in rabbits. Additionally, it was found that the MAO-treated samples could be sustained in simulated body-fluid solution, exhibiting excellent corrosion resistance and electrochemical stability. The Ca ions deposited in the MAO coating were not cytotoxic and were beneficial in enhancing bone healing after implantation.

Keywords: EDTA; In-vitro test; ZK60 magnesium alloy; biodegradability; micro-arc oxidation.

MeSH terms

Alloys / chemistry
Alloys / pharmacology
Animals
Bone and Bones*
Coated Materials, Biocompatible / chemistry
Coated Materials, Biocompatible / pharmacology
Corrosion
Magnesium* / chemistry
Magnesium* / pharmacology
Prostheses and Implants
Rabbits

Substances

Magnesium
Alloys
Coated Materials, Biocompatible

Grants and funding

This study was supported in part by Kaohsiung Medical University (KMU-TC111A020-0, KMU-TC111A02-3), and the Minister of Science and Technology of Taiwan (MOST111-2314-B-037-056). The funders had no role in the study design, data collection, and analysis, decision to publish, or preparation of the manuscript.