Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study

Sejong Jin; Eun-Ji Choi; Yoon Ji Choi; Won Kee Min; Ju Yeon Park; Seung Zhoo Yoon

doi:10.3390/ijerph20021027

Relationship between Arachidonate 5-Lipoxygenase-Activating Protein Gene and Peripheral Arterial Disease in Elderly Patients Undergoing General Surgery: A Retrospective Observational Study

Int J Environ Res Public Health. 2023 Jan 6;20(2):1027. doi: 10.3390/ijerph20021027.

Authors

Sejong Jin¹, Eun-Ji Choi², Yoon Ji Choi³, Won Kee Min³, Ju Yeon Park⁴, Seung Zhoo Yoon⁵

Affiliations

¹ Department of Neuroscience, Korea University College of Medicine, Seoul 02841, Republic of Korea.
² Department of Dental Anesthesia and Pain Medicine, School of Dentistry, Pusan National University, Dental Research Institute, Yangsan 50612, Republic of Korea.
³ Department of Anesthesiology and Pain Medicine, Korea University Ansan Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea.
⁴ Department of Anesthesiology and Pain Medicine, Daedong Hospital, Busan 47737, Republic of Korea.
⁵ Department of Anesthesiology and Pain Medicine, Korea University Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea.

Abstract

Patients with peripheral arterial disease (PAD) are at a higher risk of developing postoperative complications. Arachidonate 5-lipoxygenase-activating protein (ALOX5AP) plays an important role in atherosclerosis pathogenesis. In this study, the relationship between PAD and several single nucleotide polymorphisms (SNPs) of ALOX5AP (rs17216473, rs10507391, rs4769874, rs9551963, rs17222814, and rs7222842) was investigated in elderly patients undergoing general surgery. The medical records of 129 patients aged > 55 years who underwent elective general surgery between May 2018 and August 2019 were retrospectively reviewed. The A/A in rs17216473, A/A in rs10507391, G/G in rs4769874, and A/A in rs9551963 were calculated as 0 points and the rest as 1 point to define the genetic risk score. The prevalence of PAD tended to increase with higher genetic risk scores (patients had less ALOX5AP gene polymorphism of A/A in rs17216473, A/A in rs10507391, G/G in rs4769874, or A/A in rs9551963) (p = 0.005). Multivariate logistic regression analysis revealed that the genetic risk score (p = 0.009) and age (p = 0.007) were positively correlated with the prevalence of PAD. Genetic polymorphisms of ALOX5AP and age were associated with the prevalence of PAD in this study.

Keywords: ALOX5AP; peripheral artery disease; single nucleotide polymorphism.

Publication types

Observational Study
Research Support, Non-U.S. Gov't

MeSH terms

5-Lipoxygenase-Activating Proteins / genetics
Aged
Case-Control Studies
Genetic Predisposition to Disease*
Humans
Peripheral Arterial Disease* / epidemiology
Peripheral Arterial Disease* / genetics
Polymorphism, Single Nucleotide
Retrospective Studies
Risk Factors

Substances

5-Lipoxygenase-Activating Proteins

Grants and funding

This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI21C0262).