Antifungal Activities of Compounds Produced by Newly Isolated Acrocarpospora Strains

Ming-Jen Cheng; Jih-Jung Chen; Ming-Der Wu; Jyh-Yih Leu; Min Tseng

doi:10.3390/antibiotics12010095

Antifungal Activities of Compounds Produced by Newly Isolated Acrocarpospora Strains

Antibiotics (Basel). 2023 Jan 5;12(1):95. doi: 10.3390/antibiotics12010095.

Authors

Ming-Jen Cheng¹, Jih-Jung Chen^{2

3}, Ming-Der Wu⁴, Jyh-Yih Leu¹, Min Tseng⁴

Affiliations

¹ Department of Life Science, Fu Jen Catholic University, New Taipei City 24205, Taiwan.
² Department of Pharmacy, School of Pharmaceutical Sciences, National Yang Ming Chiao Tung University (NYCU), Taipei 112, Taiwan.
³ Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 404, Taiwan.
⁴ Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan.

Abstract

In our continued search for bioactive metabolites from cultures of rare Actinobacteria resources from all over Taiwan and various natural ecological environments, an active antimicrobial strain of Acrocarpospora punica 04107M was collected in Taitung County in Taiwan and prepared from soil. The bioassay-guided fractionation of the BuOH extract of a culture broth from A. punica 04107M led to the isolation of five previously undescribed compounds: Acrocarposporins A−E (Compounds 1−5). All the constituents were confirmed by HRESIMS and 1D- and 2D-NMR spectroscopy. Their antifungal activity was also evaluated. Our results showed that four constituents (Compounds 1, 2, 4, and 5) possessed mild antifungal activity against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae. It is worth mentioning that the chemical composition of Acrocarpospora punica 04107M has never been studied. This is the first report on diterpenoid metabolites from the genus Acrocarpospora.

Keywords: Acrocarpospora punica 04107M; Streptosporangiaceae; antifungal activities; diterpenoid.

Grants and funding

This work was kindly supported by the Ministry of Science and Technology, R.O.C. (MOST-108-2320-B-080-002-, MOST-109-2622-E-080-001-, and MOST-110-2320-B-080-001-).