In vivo single-molecule RNA structural profiling

Zhenyin Chen; Hongtao Duan; Xing Li

doi:10.1016/j.tibs.2023.01.001

In vivo single-molecule RNA structural profiling

Trends Biochem Sci. 2023 Mar;48(3):211-212. doi: 10.1016/j.tibs.2023.01.001. Epub 2023 Jan 18.

Authors

Zhenyin Chen¹, Hongtao Duan², Xing Li³

Affiliations

¹ Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, PR China; University of Chinese Academy of Science, Beijing 100049, PR China.
² Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, PR China; School of Life Science, Hebei University, Baoding, Hebei 071000, China.
³ Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing 100101, PR China; University of Chinese Academy of Science, Beijing 100049, PR China; State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: lix@biols.ac.cn.

PMID: 36670017
DOI: 10.1016/j.tibs.2023.01.001

Abstract

Cellular RNAs exhibit substantial heterogeneity in structure and function. Recently, Yang et al. developed an in vivo single-molecule RNA structure profiling methodology and revealed that individual isoforms of noncoding transcripts adopt multiple diverse and functionally relevant structural conformations, which change in abundance and structure in response to temperature conditions.

Keywords: flowering time; in vivo; long noncoding RNAs; single-molecule RNA; structural profiling; structure and function.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Gene Expression Profiling / methods
RNA*
RNA, Long Noncoding* / genetics
RNA, Messenger / genetics

Substances

RNA
RNA, Messenger
RNA, Long Noncoding