Pharmacological management of disease by overcoming structural adversity

Richard N Sifers

doi:10.1016/j.chembiol.2022.12.008

Pharmacological management of disease by overcoming structural adversity

Cell Chem Biol. 2023 Jan 19;30(1):1-2. doi: 10.1016/j.chembiol.2022.12.008.

Author

Richard N Sifers¹

Affiliation

¹ Departments of Pathology and Immunology, Molecular & Cellular Biology, and Integrative Physiology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: rsifers@bcm.edu.

PMID: 36669468
DOI: 10.1016/j.chembiol.2022.12.008

Abstract

In this issue of Cell Chemical Biology, Sun et al. utilize computational and protein expression analyses, plus pharmacological proteostasis network activation, to simultaneously correct two genetic diseases linked to a single protein rather than modify the responsible DNA.

Publication types

Comment

MeSH terms

DNA
Proteins*
Proteostasis*

Substances

Proteins
DNA