The clinical spectrum of aspergillosis in chronic obstructive pulmonary disease

Infection. 2023 Aug;51(4):813-829. doi: 10.1007/s15010-022-01960-2. Epub 2023 Jan 20.

Abstract

Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. In this review, we present the clinical spectrum and pathogenesis of syndromes caused by Aspergillus in COPD namely invasive aspergillosis (IA), community-acquired Aspergillus pneumonia, chronic pulmonary Aspergillosis and Aspergillus sensitisation. Some of these entities are clearly linked to COPD, while others may coexist, but are less clearly liked directly to COPD. We discuss current uncertainties as these pertain to IA in COPD cohorts and explore areas for future research in this field.

Keywords: Aspergillosis; Bronchiectasis; Chronic pulmonary disease.

Publication types

  • Review

MeSH terms

  • Aspergillosis* / complications
  • Aspergillus
  • Humans
  • Pulmonary Aspergillosis* / complications
  • Pulmonary Aspergillosis* / diagnosis
  • Pulmonary Disease, Chronic Obstructive* / complications