Genetic analysis of the reproductive axis in fish using genome-editing nucleases

Yun Liu; Haoran Lin

doi:10.1016/j.scib.2017.01.002

Genetic analysis of the reproductive axis in fish using genome-editing nucleases

Sci Bull (Beijing). 2017 Feb 28;62(4):302-308. doi: 10.1016/j.scib.2017.01.002. Epub 2017 Jan 4.

Authors

Yun Liu¹, Haoran Lin²

Affiliations

¹ State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: liuyun35@mail.sysu.edu.cn.
² State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals, and the Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-sen University, Guangzhou 510275, China. Electronic address: lsslhr@mail.sysu.edu.cn.

PMID: 36659358
DOI: 10.1016/j.scib.2017.01.002

Abstract

Reproduction in fish is controlled by the brain-pituitary-gonad reproductive axis. Although genes of the reproductive axis are conserved from fish to humans, their in vivo functions are less clear in fish. Mutant lines of the reproductive axis have been systematically investigated in zebrafish and medaka using recently developed genome-editing nucleases. Here, we review recent progress in the genetic analysis of the reproductive axis in fish as well as the opportunities and challenges of applying genome-editing nucleases in fisheries.

Keywords: Aquaculture; Gene knockout; Gonadotropin; Zebrafish reproduction.

Publication types

Review