Neutrophil extracellular traps and pulmonary fibrosis: an update

J Inflamm (Lond). 2023 Jan 19;20(1):2. doi: 10.1186/s12950-023-00329-y.

Abstract

Pulmonary fibrosis (PF) is a serious and often fatal illness that occurs in various clinical settings and represents a significant unmet medical need. Increasing evidence indicates that neutrophil extracellular traps (NETs) contribute significantly to the progression of PF. Therefore, understanding the pathways by which NETs contribute to the disease is crucial for developing effective treatments. This review focuses on the formation of NETs and the common mechanisms of NETs in PF.

Keywords: Interstitial lung disease; Neutrophil extracellular traps; Pulmonary fibrosis.

Publication types

  • Review