Organs-on-chips: a decade of innovation

Carly Strelez; Hannah Y Jiang; Shannon M Mumenthaler

doi:10.1016/j.tibtech.2023.01.004

Organs-on-chips: a decade of innovation

Trends Biotechnol. 2023 Mar;41(3):278-280. doi: 10.1016/j.tibtech.2023.01.004. Epub 2023 Jan 18.

Authors

Carly Strelez¹, Hannah Y Jiang², Shannon M Mumenthaler³

Affiliations

¹ Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA, USA.
² Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA.
³ Lawrence J. Ellison Institute for Transformative Medicine, Los Angeles, CA, USA; Department of Biomedical Engineering, Viterbi School of Engineering, University of Southern California, Los Angeles, CA, USA; Department of Oncology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. Electronic address: smumenthaler@eitm.org.

PMID: 36658006
DOI: 10.1016/j.tibtech.2023.01.004

Abstract

Recreating 'living organs' with groundbreaking organ-on-a-chip (OOC) technologies is facilitating a new era of drug discovery. Studies by Huh et al. and Ronaldson-Bouchard et al. underscore advances made over a decade, spanning single organ functionality to interconnected organs, that enable examination of drug toxicities and disease pathogenesis in reconstituted tissues.

Keywords: drug discovery; microphysiological systems; organ-on-a-chip.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Drug Discovery*
Lab-On-A-Chip Devices*
Microphysiological Systems

Grants and funding

R01 CA241137/CA/NCI NIH HHS/United States