Water-in-water emulsions stabilized by self-assembled chitosan colloidal particles

Wanying Cui; Chunmiao Xia; Sheng Xu; Xinke Ye; Yihao Wu; Shukai Cheng; Rongli Zhang; Cuige Zhang; Zongcheng Miao

doi:10.1016/j.carbpol.2022.120466

Water-in-water emulsions stabilized by self-assembled chitosan colloidal particles

Carbohydr Polym. 2023 Mar 1:303:120466. doi: 10.1016/j.carbpol.2022.120466. Epub 2022 Dec 13.

Authors

Wanying Cui¹, Chunmiao Xia¹, Sheng Xu², Xinke Ye¹, Yihao Wu¹, Shukai Cheng¹, Rongli Zhang³, Cuige Zhang⁴, Zongcheng Miao⁵

Affiliations

¹ Anhui Laboratory of Clean Energy Materials and Chemistry for Sustainable Conversion of Natural Resources, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China.
² Jushi Group Co., Ltd, No. 669, South Wenhua Road, Tongxiang 314500, China.
³ Anhui Laboratory of Clean Energy Materials and Chemistry for Sustainable Conversion of Natural Resources, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China. Electronic address: zrl326@163.com.
⁴ Anhui Laboratory of Clean Energy Materials and Chemistry for Sustainable Conversion of Natural Resources, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China. Electronic address: zcg17131@ahpu.edu.cn.
⁵ Anhui Laboratory of Clean Energy Materials and Chemistry for Sustainable Conversion of Natural Resources, School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China. Electronic address: miaozongcheng@xijing.edu.cn.

PMID: 36657862
DOI: 10.1016/j.carbpol.2022.120466

Abstract

Dextran (Dex) and poly(ethylene glycol) (PEG)-based aqueous emulsions were stabilized using the self-assembled chitosan colloidal particles (CS CPs). Besides, the effects of pH, CS CPs concentration, polymer concentration, volume ratio of PEG solution to Dex solution, temperature, homogenizing speed and homogenizing time on the property of the W/W emulsions were investigated, respectively. In order to enhance the stability of the PEG-Dex emulsion, sodium tripolyphosphate was used to cross-link the CS CPs at the interface of emulsion droplets, which resulted in the stability duration for >1 year. Finally, the CS CPs were used as a support to immobilize urease and bovine serum albumin and a stabilizer to prepare W/W emulsion, which were then adopted as a catalysis system and as a spinning solution to fabricate drug-loaded nanofiber. This strategy potentially provides a new opportunity to encapsulate the active molecules at the water-water interface, and enrich the types of usable active molecules in the encapsulation in the W/W emulsions.

Keywords: Chitosan; Colloidal particles; Electrospun nanofibers; Interfacial catalysis; Water-in-water emulsion.