Management of Diabetic Ketoacidosis in Pregnancy

Clin Obstet Gynecol. 2023 Mar 1;66(1):186-195. doi: 10.1097/GRF.0000000000000758. Epub 2022 Oct 10.

Abstract

Diabetic ketoacidosis (DKA) is a rare, but potentially life-threatening complication of diabetes. Certain physiological changes during pregnancy predispose pregnant individuals to developing DKA. Early recognition and aggressive treatment are essential to avoid maternal and fetal morbidity and mortality. Although laboratory values can help to support, pregnant patients with DKA may not meet the usual criteria and the diagnosis can be made clinically. The key components to treatment include volume replacement, insulin infusion, correction of serum potassium, and fetal monitoring. With appropriate treatment, maternal mortality is low. After recovery, steps should be taken to avoid recurrence.

MeSH terms

  • Diabetes Mellitus*
  • Diabetic Ketoacidosis* / diagnosis
  • Diabetic Ketoacidosis* / therapy
  • Female
  • Fetal Monitoring
  • Fetus
  • Humans
  • Pregnancy
  • Pregnancy in Diabetics* / therapy
  • Prenatal Care