Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events

Ying Jing; Jingwen Yang; Leng Han

doi:10.1016/j.xcrm.2022.100902

Distinct T cell sub-clusters may serve as biomarkers for immune related adverse events

Cell Rep Med. 2023 Jan 17;4(1):100902. doi: 10.1016/j.xcrm.2022.100902.

Authors

Ying Jing¹, Jingwen Yang², Leng Han³

Affiliations

¹ Clinical Research Institute, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: yingjing@sjtu.edu.cn.
² Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA.
³ Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX, USA; Department of Translational Medical Sciences, College of Medicine, Texas A&M University, Houston, TX, USA. Electronic address: leng.han@tamu.edu.

Abstract

Identifying biomarkers of irAEs is the prerequisite for maximizing clinical benefits of patients treated by immune checkpoint inhibitors. Bukhari et al.¹ identified significant associations between different peripheral T cell sub-clusters and arthritis, pneumonitis, and thyroiditis.

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MeSH terms

Biomarkers
Humans
T-Lymphocytes*

Substances

Biomarkers