Soy protein isolate-polyguluronate nanoparticles loaded with resveratrol for effective treatment of colitis

Wenhao Li; Decheng Bi; Jiang Yi; Lijun Yao; Jue Cao; Peng Yang; Meiting Li; Yan Wu; Hong Xu; Zhangli Hu; Xu Xu

doi:10.1016/j.foodchem.2023.135418

Soy protein isolate-polyguluronate nanoparticles loaded with resveratrol for effective treatment of colitis

Food Chem. 2023 Jun 1:410:135418. doi: 10.1016/j.foodchem.2023.135418. Epub 2023 Jan 5.

Authors

Wenhao Li¹, Decheng Bi², Jiang Yi³, Lijun Yao⁴, Jue Cao⁴, Peng Yang⁵, Meiting Li⁶, Yan Wu⁷, Hong Xu⁴, Zhangli Hu⁴, Xu Xu⁸

Affiliations

¹ Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; Shenzhen Synthetic Biology Infrastructure, Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences, Shenzhen 518055, China.
² Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.
³ Department of Food Science and Technology, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China.
⁴ Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China.
⁵ Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; College of Food Science and Engineering, Ocean University of China 266003, China.
⁶ Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China; Quality and Standards Academy, Shenzhen Technology University, 518118, China.
⁷ Instrumental Analysis Center of Shenzhen University, 518060, China.
⁸ Shenzhen Key Laboratory of Marine Bioresources and Ecology, College of Life Sciences and Oceanography, Shenzhen University, Shenzhen 518060, China. Electronic address: xuxu@szu.edu.cn.

PMID: 36652800
DOI: 10.1016/j.foodchem.2023.135418

Abstract

Polyguluronate (PG) is an acidic homopolymer of α-(1,4)-l-guluronate separated from alginate. In this study, PG was first grafted with soy protein isolate (SPI) through the Maillard reaction to obtain a new glycoprotein (SPI-PG). Then, this novel glycoprotein was used to prepare nanoparticles to encapsulate the resveratrol (RES). Our results showed that SPI-PG-RES had better pH stability, storage stability and ionic stability than SPI-RES. In vitro digestion experiments showed that the RES bioavailability of SPI-PG-RES was much higher than that of free RES and SPI-RES. Furthermore, the in vitro antioxidant capacity of SPI-PG-RES was much stronger than that of free RES and SPI-RES. In addition, SPI-PG-RES was more effective in preventing the symptoms of DSS-induced colitis than RES and SPI-RES. These results suggested that the protein nanoparticles prepared using SPI-PG were a stable and effective hydrophobic polyphenol carrier and could be applied to food-grade components in functional foods and nutritional supplements.

Keywords: Antioxidant; Bioavailability; Colitis; Nanoparticles; Polyguluronate; Resveratrol.

MeSH terms

Antioxidants / chemistry
Nanoparticles* / chemistry
Resveratrol
Soybean Proteins* / chemistry

Substances

Resveratrol
polyguluronic acid
Soybean Proteins
Antioxidants