Neurodegenerative disease of the brain: a survey of interdisciplinary approaches

Franca Davenport; John Gallacher; Zoe Kourtzi; Ivan Koychev; Paul M Matthews; Neil P Oxtoby; Laura M Parkes; Viola Priesemann; James B Rowe; Stephen W Smye; Henrik Zetterberg

doi:10.1098/rsif.2022.0406

Neurodegenerative disease of the brain: a survey of interdisciplinary approaches

J R Soc Interface. 2023 Jan;20(198):20220406. doi: 10.1098/rsif.2022.0406. Epub 2023 Jan 18.

Authors

Franca Davenport¹, John Gallacher², Zoe Kourtzi³, Ivan Koychev^{4

5}, Paul M Matthews⁶, Neil P Oxtoby⁷, Laura M Parkes^{8

9}, Viola Priesemann¹⁰, James B Rowe¹¹, Stephen W Smye¹², Henrik Zetterberg^{13

14

15

16

17}

Affiliations

¹ Freelance writer and King's College London, London, UK.
² Director of Dementias Platform, Department of Psychiatry, University of Oxford, Oxford, UK.
³ Professor of Cognitive Computational Neuroscience, Department of Psychology, University of Cambridge, UK.
⁴ Senior Clinical Researcher, Department of Psychiatry, University of Oxford, Oxford, UK.
⁵ Consultant Neuropsychiatrist, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
⁶ Department of Brain Sciences and UK Dementia Research Institute Centre, Imperial College London, Oxford, UK.
⁷ UCL Centre for Medical Image Computing and Department of Computer Science, University College London, Gower Street, London, UK.
⁸ School of Health Sciences, Faculty of Biology, Medicine and Health, The University of Manchester, Oxford Road, Manchester, M13 9PL, UK.
⁹ Geoffrey Jefferson Brain Research Centre, Manchester Academic Health Science Centre, Manchester, UK.
¹⁰ Max Planck Group Leader and Fellow of the Schiemann Kolleg, Max Planck Institute for Dynamics and Self-Organization and Bernstein Center for Computational Neuroscience, Göttingen, Germany.
¹¹ Department of Clinical Neurosciences, MRC Cognition and Brain Sciences Unit and Cambridge University Hospitals NHS Trust, University of Cambridge, Cambridge, UK.
¹² School of Medicine, University of Leeds, Leeds, UK.
¹³ Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, UK.
¹⁴ Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
¹⁵ Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
¹⁶ UK Dementia Research Institute at UCL, London, UK.
¹⁷ Hong Kong Center for Neurodegenerative Diseases, Clear Water Bay, Hong Kong, People's Republic of China.

Abstract

Neurodegenerative diseases of the brain pose a major and increasing global health challenge, with only limited progress made in developing effective therapies over the last decade. Interdisciplinary research is improving understanding of these diseases and this article reviews such approaches, with particular emphasis on tools and techniques drawn from physics, chemistry, artificial intelligence and psychology.

Keywords: brain; data; imaging; models; neurodegenerative diseases; physics.

Neurodegenerative disease of the brain: a survey of interdisciplinary approaches

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