Operational Tolerance after Liver Transplantation: First Report from India

Vikrant Sood; Bikrant B Lal; N S Ashwini; Rajeev Khanna; Viniyendra Pamecha; Nirupama Trehanpati; Seema Alam

doi:10.1016/j.jceh.2022.09.002

Operational Tolerance after Liver Transplantation: First Report from India

J Clin Exp Hepatol. 2023 Jan-Feb;13(1):178-181. doi: 10.1016/j.jceh.2022.09.002. Epub 2022 Sep 17.

Authors

Vikrant Sood¹, Bikrant B Lal¹, N S Ashwini², Rajeev Khanna¹, Viniyendra Pamecha³, Nirupama Trehanpati⁴, Seema Alam¹

Affiliations

¹ Department of Pediatric Hepatology, New Delhi 110070, India.
² Department of Hepatopathology, New Delhi 110070, India.
³ Department of Hepato-pancreato-biliary Surgery and Liver Transplantation, New Delhi 110070, India.
⁴ Department of Molecular and Cellular Medicine, Institute of Liver and Biliary Sciences, New Delhi 110070, India.

Abstract

Operational tolerance after liver transplantation is an ideal goal to avoid long-term morbidities associated with chronic immunosuppressive medication use. It is achievable in a highly selected group of post-transplant recipients but requires long-term follow-up and strict monitoring. We hereby report a post-transplant case who achieved spontaneous operational tolerance after inadvertent immunosuppression withdrawal.

Keywords: DSA, donor-specific antibody; LT, liver transplantation; hepatic graft rejection; immunosuppression withdrawal; operational tolerance; pediatric liver transplantation.

Publication types

Case Reports