Large-scale multimodal surface neural interfaces for primates

Tiphaine Belloir; Sergio Montalgo-Vargo; Zabir Ahmed; Devon J Griggs; Shawn Fisher; Timothy Brown; Maysamreza Chamanzar; Azadeh Yazdan-Shahmorad

doi:10.1016/j.isci.2022.105866

Large-scale multimodal surface neural interfaces for primates

iScience. 2022 Dec 26;26(1):105866. doi: 10.1016/j.isci.2022.105866. eCollection 2023 Jan 20.

Authors

Tiphaine Belloir^{1

2}, Sergio Montalgo-Vargo³, Zabir Ahmed³, Devon J Griggs^{2

4}, Shawn Fisher^{1

2}, Timothy Brown⁵, Maysamreza Chamanzar^{3

6

7}, Azadeh Yazdan-Shahmorad^{1

2

4}

Affiliations

¹ Department of Bioengineering, University of Washington, Seattle, WA, USA.
² Washington National Primate Research Center, Seattle, WA, USA.
³ Department of Electrical and Computer Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
⁴ Department of Electrical and Computer Engineering, University of Washington, Seattle, WA, USA.
⁵ Department of Bioethics & Humanities, University of Washington, Seattle, WA, USA.
⁶ Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, USA.
⁷ Carnegie Mellon Neuroscience Institute, Pittsburgh, PA, USA.

Abstract

Deciphering the function of neural circuits can help with the understanding of brain function and treating neurological disorders. Progress toward this goal relies on the development of chronically stable neural interfaces capable of recording and modulating neural circuits with high spatial and temporal precision across large areas of the brain. Advanced innovations in designing high-density neural interfaces for small animal models have enabled breakthrough discoveries in neuroscience research. Developing similar neurotechnology for larger animal models such as nonhuman primates (NHPs) is critical to gain significant insights for translation to humans, yet still it remains elusive due to the challenges in design, fabrication, and system-level integration of such devices. This review focuses on implantable surface neural interfaces with electrical and optical functionalities with emphasis on the required technological features to realize scalable multimodal and chronically stable implants to address the unique challenges associated with nonhuman primate studies.

Keywords: Neuroscience; Optoelectronics.

Publication types

Review

Abstract

Publication types

Grants and funding