Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600)

Khadijeh Hamidian; Mahmood Barani; Mahboubeh Adeli-Sardou; Mina Sarani; Saba Daliran; Ali Raza Oveisi

doi:10.1016/j.heliyon.2022.e12634

Evaluation of cytotoxicity, loading, and release activity of paclitaxel loaded-porphyrin based metal-organic framework (PCN-600)

Heliyon. 2022 Dec 26;9(1):e12634. doi: 10.1016/j.heliyon.2022.e12634. eCollection 2023 Jan.

Authors

Khadijeh Hamidian¹, Mahmood Barani², Mahboubeh Adeli-Sardou^{3

4}, Mina Sarani⁵, Saba Daliran⁶, Ali Raza Oveisi⁶

Affiliations

¹ Department of Pharmaceutics, Faculty of Pharmacy, Zabol University of Medical Sciences, Zabol, Iran.
² Medical Mycology and Bacteriology Research Center, Kerman University of Medical Sciences, 76169-13555, Kerman, Iran.
³ Herbal and Traditional Medicines Research Center, Kerman University of Medical Sciences, Kerman, Iran.
⁴ Department of Biotechnology, Institute of Science and High Technology and Environmental Sciences, Graduate University of Advanced Technology, Kerman, Iran.
⁵ Zabol Medicinal Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran.
⁶ Department of Chemistry, University of Zabol, P.O. Box: 98615-538, Zabol 9861335856, Iran.

Abstract

Considering the inducement side impacts and precipitation of continual doses in conventional therapeutic treatments, there is an urgent need in the field of drug delivery for novel designs of biocompatible carriers with wide loading dimensions and particularly the ability to control their drug release. In this work, we succeeded in synthesizing an iron-based organic metal framework based on iron-porphyrin (PCN-600) through a solvothermal method to function as a drug delivery system (DDS). According to SEM results, PCN-600 crystals a hexagonal-rod shaped morphology with the length of 300 nm and width of 100-300 nm. As an anticancer drug, Paclitaxel (PTX) was successfully loaded into the porphyrin-based metal-organic framework (PCN-600) via in-situ encapsulation; the loading efficiency was measured to be about 87.3%. In addition, PTX-encapsulated PCN-600 displayed a controlled and sustained release for up to 24 h of release assessment at the physiological microenvironment of pH = 7.4.

Keywords: Anticancer drugs; Drug delivery; Metal-organic frameworks; PCN-600; Paclitaxel.