Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

Ao-Ran Liu; Zhi Lv; Zi-Wei Yan; Xiao-Yang Wu; Li-Rong Yan; Li-Ping Sun; Yuan Yuan; Qian Xu

doi:10.1186/s12967-023-03878-1

Association of mitochondrial homeostasis and dynamic balance with malignant biological behaviors of gastrointestinal cancer

J Transl Med. 2023 Jan 16;21(1):27. doi: 10.1186/s12967-023-03878-1.

Authors

Ao-Ran Liu^{1

2

3}, Zhi Lv^{1

2

3}, Zi-Wei Yan^{1

2

3}, Xiao-Yang Wu^{1

2

3}, Li-Rong Yan^{1

2

3}, Li-Ping Sun^#^{4

5

6}, Yuan Yuan^#^{7

8

9}, Qian Xu^#^{10

11

12}

Affiliations

¹ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China.
² Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China.
³ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China.
⁴ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. lpsun@cmu.edu.cn.
⁵ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. lpsun@cmu.edu.cn.
⁶ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. lpsun@cmu.edu.cn.
⁷ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. yuanyuan@cmu.edu.cn.
⁸ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. yuanyuan@cmu.edu.cn.
⁹ Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. yuanyuan@cmu.edu.cn.
¹⁰ Tumor Etiology and Screening Department of Cancer Institute and General Surgery, The First Hospital of China Medical University, No. 155 North NanjingBei Street, Heping District, Shenyang, 110001, Liaoning, People's Republic of China. qxu@cmu.edu.cn.
¹¹ Key Laboratory of Cancer Etiology and Prevention in Liaoning Education Department, The First Hospital of China Medical University, Shenyang, 110001, China. qxu@cmu.edu.cn.
¹² Key Laboratory of GI Cancer Etiology and Prevention in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China. qxu@cmu.edu.cn.

^# Contributed equally.

Abstract

Mitochondria determine the physiological status of most eukaryotes. Mitochondrial dynamics plays an important role in maintaining mitochondrial homeostasis, and the disorder in mitochondrial dynamics could affect cellular energy metabolism leading to tumorigenesis. In recent years, disrupted mitochondrial dynamics has been found to influence the biological behaviors of gastrointestinal cancer with the potential to be a novel target for its individualized therapy. This review systematically introduced the role of mitochondrial dynamics in maintaining mitochondrial homeostasis, and further elaborated the effects of disrupted mitochondrial dynamics on the cellular biological behaviors of gastrointestinal cancer as well as its association with cancer progression. We aim to provide clues for elucidating the etiology and pathogenesis of gastrointestinal cancer from the perspective of mitochondrial homeostasis and disorder.

Keywords: Fission; Fusion; Gastrointestinal cancer; Mitochondria; Mitochondrial biogenesis; Mitochondrial dynamic; Mitochondrial homeostasis; Mitochondrial quality control; Mitophagy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Carcinogenesis / pathology
Gastrointestinal Neoplasms* / metabolism
Gastrointestinal Neoplasms* / pathology
Homeostasis
Humans
Mitochondria* / metabolism
Mitochondrial Dynamics