Engineered membrane receptors with customizable input and output functions

Justin A Peruzzi; Timothy Q Vu; Neha P Kamat

doi:10.1016/j.tibtech.2023.01.002

Engineered membrane receptors with customizable input and output functions

Trends Biotechnol. 2023 Mar;41(3):276-277. doi: 10.1016/j.tibtech.2023.01.002. Epub 2023 Jan 14.

Authors

Justin A Peruzzi¹, Timothy Q Vu², Neha P Kamat³

Affiliations

¹ Department of Chemical and Biological Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, USA; Center for Synthetic Biology, Northwestern University, Evanston, IL, USA.
² Center for Synthetic Biology, Northwestern University, Evanston, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, USA.
³ Center for Synthetic Biology, Northwestern University, Evanston, IL, USA; Department of Biomedical Engineering, McCormick School of Engineering and Applied Science, Northwestern University, Evanston, IL, USA. Electronic address: nkamat@northwestern.edu.

Abstract

Morsut et al. reported a synthetic receptor system, based on the natural Notch receptor, with customizable input and output functions. Their work on advanced receptor design expands the reach of synthetic receptor systems. Incorporating new protein design tools with better-understood membrane biophysics will create the next generation of engineered receptors.

MeSH terms

Protein Engineering*
Receptors, Artificial*

Substances

Receptors, Artificial

Grants and funding

T32 GM008449/GM/NIGMS NIH HHS/United States