A new alkaloid derivative from the saprophytic fungus Neohelicomyces hyalosporus PF11-1

Wen Zheng; Long Han; Zhang-Jiang He; Ji-Chuan Kang

doi:10.1080/14786419.2023.2167202

A new alkaloid derivative from the saprophytic fungus Neohelicomyces hyalosporus PF11-1

Nat Prod Res. 2023 Jan 16:1-5. doi: 10.1080/14786419.2023.2167202. Online ahead of print.

Authors

Wen Zheng^{1

2}, Long Han^{1

2}, Zhang-Jiang He², Ji-Chuan Kang^{1

2}

Affiliations

¹ College of Life Sciences, Guizhou University, Guiyang, P.R. China.
² Engineering Research Center of the Utilization for Characteristic Bio-Pharmaceutical Resources in Southwest, Ministry of Education, Guiyang, P.R. China.

PMID: 36644981
DOI: 10.1080/14786419.2023.2167202

Abstract

A new alkaloid, neohelicomyine A (1), along with two known alkaloids (2-3), were isolated from the fermentation of Neohelicomyces hyalosporus PF11-1. The structures of these compounds were elucidated by extensive analyses of spectroscopic methods including 1 D and 2 D NMR, HRESIMS and ECD. The bioactivities of all compounds were evaluated using cellular assays, and compounds 2 and 3 displayed moderate cytotoxicities against human cancer (A549, TCA, RD) cells with IC₅₀ values of 26-87 μg/mL.

Keywords: Neohelicomyces hyalosporus; Saprophytic fungi; alkaloid; cytotoxicity.