Korean Red Ginseng modulates immune function by upregulating CD4+CD8+ T cells and NK cell activities on porcine

Md Jahangir Alam; Mohammad Amjad Hossain; Kiran D Bhilare; Chang-Won Kang; Jong-Hoon Kim

doi:10.1016/j.jgr.2022.10.002

Korean Red Ginseng modulates immune function by upregulating CD4⁺CD8⁺ T cells and NK cell activities on porcine

J Ginseng Res. 2023 Jan;47(1):155-158. doi: 10.1016/j.jgr.2022.10.002. Epub 2022 Oct 18.

Authors

Md Jahangir Alam¹, Mohammad Amjad Hossain¹, Kiran D Bhilare¹, Chang-Won Kang¹, Jong-Hoon Kim¹

Affiliation

¹ College of Veterinary Medicine, Biosafety Research Institute, Jeonbuk National University, Iksan, Republic of Korea.

Abstract

In the present study, we investigated whether treatment with KRG improve the parameters of immune activity such as the cytotoxicity, populations of CD4⁺ CD8⁺T cell, CD3^-CD172^-CD8⁺ NK cell and CD172⁺ monocyte as well as natural cytotoxicity receptors such as Nkp46, Nkp44, Nkp30. In results, KRG significantly increased these immune activities. These results indicate that KRG has distinct immune-enhancing effects by increasing the roles of T cells and NK cell in porcine.

Keywords: CD4+ CD8+T cell; Korean Red Ginseng; cytotoxic receptors; immune activity.