Titanium-Based Nanoarchitectures for Sonodynamic Therapy-Involved Multimodal Treatments

Aziz Maleki; Mohammad Seyedhamzeh; Meng Yuan; Tarun Agarwal; Ibrahim Sharifi; Abbas Mohammadi; Pelin Kelicen-Uğur; Mehrdad Hamidi; Massoud Malaki; Abdulaziz A Al Kheraif; Ziyong Cheng; Jun Lin

doi:10.1002/smll.202206253

Titanium-Based Nanoarchitectures for Sonodynamic Therapy-Involved Multimodal Treatments

Small. 2023 Mar;19(12):e2206253. doi: 10.1002/smll.202206253. Epub 2023 Jan 15.

Authors

Aziz Maleki¹, Mohammad Seyedhamzeh¹, Meng Yuan², Tarun Agarwal³, Ibrahim Sharifi⁴, Abbas Mohammadi⁵, Pelin Kelicen-Uğur⁶, Mehrdad Hamidi^{7

8}, Massoud Malaki⁹, Abdulaziz A Al Kheraif¹⁰, Ziyong Cheng^{2

11}, Jun Lin²

Affiliations

¹ Zanjan Pharmaceutical Nanotechnology Research Center (ZPNRC), and Department of Pharmaceutical Nanotechnology School of pharmacy, Zanjan University of Medical Sciences, Zanjan, 4513956184, Iran.
² State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China.
³ Department of Bio-Technology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, 721302, India.
⁴ Department of Materials Engineering, Faculty of Engineering, Shahrekord University, Shahrekord, 64165478, Iran.
⁵ Department of Chemistry, University of Isfahan, Isfahan, 81746-73441, Iran.
⁶ Faculty of Pharmacy, Department of Pharmacology, Hacettepe University, Sıhhiye, Ankara, 06430, Turkey.
⁷ Department of Pharmaceutical Nanotechnology, School of pharmacy, Zanjan University of Medical Sciences, Zanjan, 4513956184, Iran.
⁸ Trita Nanomedicine Research & Technology Development Center (TNRTC), Zanjan Health Technology Park, Zanjan, 45156-13191, Iran.
⁹ Department of Mechanical Engineering, Faculty of Engineering, Isfahan University of Technology, Isfahan, Iran.
¹⁰ Dental Health Department, College of Applied Medical Sciences, King Saud University, Riyadh, 12372, Saudi Arabia.
¹¹ Guangdong Provincial Key Laboratory of Research and Development of Natural Drugs, and School of Pharmacy, Guangdong Medical University, Guangdong Medical University Key Laboratory of Research and Development of New Medical Materials, Dongguan, 523808, China.

PMID: 36642806
DOI: 10.1002/smll.202206253

Abstract

Sonodynamic therapy (SDT) has considerably revolutionized the healthcare sector as a viable noninvasive therapeutic procedure. It employs a combination of low-intensity ultrasound and chemical entities, known as a sonosensitizer, to produce cytotoxic reactive oxygen species (ROS) for cancer and antimicrobial therapies. With nanotechnology, several unique nanoplatforms are introduced as a sonosensitizers, including, titanium-based nanomaterials, thanks to their high biocompatibility, catalytic efficiency, and customizable physicochemical features. Additionally, developing titanium-based sonosensitizers facilitates the integration of SDT with other treatment modalities (for example, chemotherapy, chemodynamic therapy, photodynamic therapy, photothermal therapy, and immunotherapy), hence increasing overall therapeutic results. This review summarizes the most recent developments in cancer therapy and tissue engineering using titanium nanoplatforms mediated SDT. The synthesis strategies and biosafety aspects of Titanium-based nanoplatforms for SDT are also discussed. Finally, various challenges and prospects for its further development and potential clinical translation are highlighted.

Keywords: biomedical application; sonodynamic therapy; sonosensitizers; titanium; ultrasound.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents* / therapeutic use
Cell Line, Tumor
Combined Modality Therapy
Humans
Neoplasms* / drug therapy
Reactive Oxygen Species
Titanium
Ultrasonic Therapy* / methods

Substances

Titanium
Antineoplastic Agents
Reactive Oxygen Species