Sustainable γ-cyclodextrin frameworks containing ultra-fine silver nanoparticles with enhanced antimicrobial efficacy

Hessah Alotaibi; Etelka Chung; Se Hun Chung; Guogang Ren; Vikramjeet Singh; Jie Huang

doi:10.1016/j.carbpol.2022.120516

Sustainable γ-cyclodextrin frameworks containing ultra-fine silver nanoparticles with enhanced antimicrobial efficacy

Carbohydr Polym. 2023 Mar 15:304:120516. doi: 10.1016/j.carbpol.2022.120516. Epub 2022 Dec 30.

Authors

Hessah Alotaibi¹, Etelka Chung², Se Hun Chung³, Guogang Ren⁴, Vikramjeet Singh⁵, Jie Huang⁶

Affiliations

¹ Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; Department of Biomedical Engineering, King Faisal University, Hofuf 31982, Saudi Arabia.
² School of Engineering & Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK.
³ Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK.
⁴ School of Engineering & Computer Science, University of Hertfordshire, Hatfield AL10 9AB, UK. Electronic address: g.g.ren@herts.ac.uk.
⁵ Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK; Nanoengineered Systems Laboratory, UCL Mechanical Engineering, University College London, London WC1E 7JE, UK. Electronic address: vikramjeet.singh@ucl.ac.uk.
⁶ Department of Mechanical Engineering, University College London, Torrington Place, London WC1E 7JE, UK. Electronic address: jie.huang@ucl.ac.uk.

PMID: 36641162
DOI: 10.1016/j.carbpol.2022.120516

Abstract

Cyclodextrin metal-organic frameworks (CD-MOF) are a class of biocompatible MOF with a great potential in drug delivery applications. Original CD-MOF crystals are fragile and large (0.2-1 mm), which are less useful in pharmaceutical applications. Cetyltrimethylammonium bromide and long chain poly(ethylene) glycol, used in size modulation to produce nanosized CD-MOF can compromise the biocompatibility, and physiochemical properties of CD-MOF as their complete removal from frameworks is difficult. To avoid the use of above-mentioned modulators, herein, we demonstrate the synthesis of nanosized CD-MOF using triethylamine (TEA) as a modulator to reduce their size to ~254 nm. The MOF characteristics such as crystal and chemical structure remain unaffected and the surface area of CD-MOF synthesised with TEA is measured 1075.5 m²/g, almost 50 % higher than those of synthesised using bulky modulators. The improved CD-MOF architecture utilized for the in-situ synthesis of silver nanoparticles resulted in enhanced antimicrobial efficacy tested against Staphylococcus aureus and Escherichia coli bacteria and Candida albicans fungus. And minimum inhibitory concentration (MIC) is recorded in the range of 31-15 μg/mL. Overall, the structural improvement in CD-MOF supported with thorough comparative investigations and enhanced antimicrobial efficacy could be very helpful in further establishing them in biomedicine field.

Keywords: Antimicrobial; Cyclodextrin metal-organic frameworks; Modulators; Silver nanoparticles; Triethylamine.

MeSH terms

Anti-Infective Agents*
Cyclodextrins* / chemistry
Metal Nanoparticles*
Metal-Organic Frameworks* / chemistry
Polyethylene Glycols
Silver / pharmacology
gamma-Cyclodextrins* / chemistry
gamma-Cyclodextrins* / pharmacology

Substances

gamma-Cyclodextrins
Silver
Cyclodextrins
Metal-Organic Frameworks
Anti-Infective Agents
Polyethylene Glycols