Second near-infrared window fluorescence nanoprobes for deep-tissue in vivo multiplexed bioimaging

Yanling Yang; Yang Xie; Fan Zhang

doi:10.1016/j.addr.2023.114697

Second near-infrared window fluorescence nanoprobes for deep-tissue in vivo multiplexed bioimaging

Adv Drug Deliv Rev. 2023 Feb:193:114697. doi: 10.1016/j.addr.2023.114697. Epub 2023 Jan 11.

Authors

Yanling Yang¹, Yang Xie², Fan Zhang³

Affiliations

¹ State Key Laboratory of Analytical Chemistry for Life Science, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023 China.
² Department of Orthopaedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. Electronic address: doctorx@smmu.edu.cn.
³ Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers and iChem, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433 China; College of Energy Materials and Chemistry, Inner Mongolia University, Hohhot 010021, China. Electronic address: zhang_fan@fudan.edu.cn.

PMID: 36641080
DOI: 10.1016/j.addr.2023.114697

Abstract

In vivo multiplexed bioimaging in the second near-infrared window (NIR-II, 1000-1700 nm), owing to its superiorities of simultaneous multi-channel (multicolor) observations for multiple intrinsic biomarkers, high sensitivity, deeper penetration and high spatiotemporal resolution, and high throughput, has been a growing technology in fundamental medical diagnosis and clinical applications. Among several NIR-II nanoprobes for multiplexed bioimaging, the inorganic nanoprobes based on quantum dots (QDs) and lanthanide downconversion nanoparticles (DCNPs), as well as organic fluorophores based on donor-acceptor-donor (D-A-D) chromophores, polymethine dyes, and lanthanide complexes are extensively suitable for intravital imaging and diagnosis of disease, exhibiting excellent accomplishments. Here, we summarize recent advances in NIR-II-emitted nanoprobes for intravital multiplexed bioimaging. Furthermore, the current challenges and potential opportunities in designing novel long-wavelength nanoprobes for deep-tissue intravital multiplexed bioimaging are discussed.

Keywords: In vivo multiplexed bioimaging; Inorganic fluorescence nanoprobes; Organic fluorescence nanoprobes; Organic-inorganic composites; The second near-infrared window.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Fluorescence
Fluorescent Dyes
Humans
Lanthanoid Series Elements*
Nanoparticles*
Optical Imaging / methods
Quantum Dots*

Substances

Lanthanoid Series Elements
Fluorescent Dyes