Distribution in marine fish and EDI estimation of contaminants of emerging concern by vortex-assisted matrix solid-phase dispersion and HPLC-MS/MS

Karina Lotz Soares; Adrià Sunyer-Caldú; Ednei Gilberto Primel; Gilberto Fillmann; M Silvia Diaz-Cruz

doi:10.1016/j.marpolbul.2022.114530

Distribution in marine fish and EDI estimation of contaminants of emerging concern by vortex-assisted matrix solid-phase dispersion and HPLC-MS/MS

Mar Pollut Bull. 2023 Feb:187:114530. doi: 10.1016/j.marpolbul.2022.114530. Epub 2023 Jan 12.

Authors

Karina Lotz Soares¹, Adrià Sunyer-Caldú², Ednei Gilberto Primel³, Gilberto Fillmann¹, M Silvia Diaz-Cruz⁴

Affiliations

¹ Instituto de Oceanografia, Universidade Federal do Rio Grande (IO - FURG), Av. Itália s/n, Campus Carreiros, C.P. 474, 96201-900 Rio Grande, RS, Brazil; PPG em Oceanologia, Universidade Federal do Rio Grande (PPGO - FURG), Av. Itália s/n, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil; PPG em Química Tecnológica e Ambiental, Universidade Federal do Rio Grande (PPGQTA - FURG), Av. Itália s/n, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil.
² Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA), Severo Ochoa Excellence Center. Consejo Superior de Investigaciones Cientificas (CSIC), Jordi Girona 18, 08034 Barcelona, Spain.
³ PPG em Química Tecnológica e Ambiental, Universidade Federal do Rio Grande (PPGQTA - FURG), Av. Itália s/n, Campus Carreiros, 96203-900 Rio Grande, RS, Brazil.
⁴ Department of Environmental Chemistry, Institute of Environmental Assessment and Water Research (IDAEA), Severo Ochoa Excellence Center. Consejo Superior de Investigaciones Cientificas (CSIC), Jordi Girona 18, 08034 Barcelona, Spain. Electronic address: sdcqam@cid.csic.es.

PMID: 36640500
DOI: 10.1016/j.marpolbul.2022.114530

Abstract

Due to their persistence or continuous discharge, toxic substances are present in the aquatic environment, and can bioaccumulate and biomagnify in the food web, generating a significant ecological risk and a threat to human health. The present study assess the occurrence and tissue (muscle, liver, stomach and gills) distribution of 59 anthropogenic contaminants of emerging concern (CECs) in marine fish from Brazil. A simpler and faster analytical methodology based on vortex-assisted matrix solid-phase dispersion (VA-MSPD) and liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) was developed and validated. Limits of quantification ranged from 3.31 to 114 ng g^-1 dw with recovery rates between 60 and 140 % and relative standard deviation below 20 %. The ultraviolet filters 4-hydroxybenzophenone (4HB) (benzophenone-3 metabolite) and benzocaine (Et-PABA), and the antibacterial salicylic acid were frequently accumulated in muscle and liver at concentrations between 39.5 and 21.0 ngg^-1 dw. The determined concentrations resulted to be lower than the tolerable daily intake recommended by the European Food Safety Authority (EFSA).

Keywords: Biocides; EDI; Fish; Personal care products; Pharmaceuticals; VA-MSPD.

MeSH terms

Animals
Chromatography, High Pressure Liquid / methods
Chromatography, Liquid / methods
Fishes* / metabolism
Humans
Liver / chemistry
Solid Phase Extraction / methods
Tandem Mass Spectrometry* / methods