Reveal the mechanisms of prescriptions for liver cancer' treatment based on two illustrious senior TCM physicians

Wang Bochuan; Zhang Yong; Zhang Qiuyun; Zhang Zhiqiang; Luo Changyong; Wang Zhendong; Bai Chen; Wang Yuhan; G E Xueyi; Qian Ying; Y U He; G U Xiaohong

doi:10.19852/j.cnki.jtcm.20221013.001

Reveal the mechanisms of prescriptions for liver cancer' treatment based on two illustrious senior TCM physicians

J Tradit Chin Med. 2023 Feb;43(1):188-197. doi: 10.19852/j.cnki.jtcm.20221013.001.

Authors

Wang Bochuan¹, Zhang Yong², Zhang Qiuyun³, Zhang Zhiqiang⁴, Luo Changyong⁵, Wang Zhendong¹, Bai Chen¹, Wang Yuhan¹, G E Xueyi², Qian Ying³, Y U He¹, G U Xiaohong¹

Affiliations

¹ School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 10029, China.
² Liver Disease Branch, Shandong Hospital of Traditional Chinese Medicine, Jinan 250013, China.
³ School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China.
⁴ Beijing Tcmages Pharmaceutical Co., Ltd., Beijing 101399, China.
⁵ Dongfang Hospital Beijing University of Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100078, China.

Abstract

Objective: To explore the core herbs of two illustrious senior Traditional Chinese Medicine (TCM) Physicians for the treatment of liver cancer, and to further clarify the gene targets and pathway mechanisms of liver cancer that the core prescription (CP) may regulate.

Methods: We used the patient information of two illustrious senior TCM physicians from the Affiliated Hospital of Shandong University of Traditional Chinese Medicine and the Affiliated Hospital of Capital Medical University as the database. The CP was analyzed using the community network algorithm. The pathway mechanism was analyzed using network pharmacology method. And the prognostic survival genes were identified using Single factor cox regression analysis. Integrative Pharmacology-based Research Platform of Traditional Chinese Medicine (TCMIP), Herb, Online Mendelian Inheritance in Man (OMIM), Genecards, Kyoto Encyclopedia of Genes and Genomes (KEGG), Genomic Data Commons (GDC), The Cancer Genome Atlas (TCGA), Gephi and R were used to mine CP, building a pathway network diagram. All the analyses were visualized.

Results: We found that the CP consistes of Huangqi (), Danshen (), Shuihonghuazi (), Baihuasheshecao (), Banzhilian (), and Ezhu (), which were attributed to the two physicians respectively. The CP played an anti-cancer role through such pathways as signal transduction, energy metabolism, immune system and other pathways, covering a total of 112 pathways and 176 herb-disease-related genes. Fourteen genes have a significant impact on the prognosis and survival of liver cancer.

Conclusion: Based on the liver cancer cases of two illustrious senior TCM physicians, we obtained the CP through data mining. The CP may mainly exert anti-cancer effects by inhibiting inflammatory response, angiogenesis, and enhancing the body's immune response. We screened out 14 genes in the CP that may be related to the prognosis of liver cancer, and these genes may play an important regulatory role in the prognosis of liver cancer.

Keywords: bioinformatics analysis; liver neoplasms; machine learning; medicine, Chinese traditional; network analysis; prognosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Data Mining
Databases, Factual
Drugs, Chinese Herbal* / therapeutic use
Humans
Liver Neoplasms* / drug therapy
Liver Neoplasms* / genetics
Medicine, Chinese Traditional

Substances

Drugs, Chinese Herbal