Protein structure prediction has reached the single-structure frontier

Nat Methods. 2023 Feb;20(2):170-173. doi: 10.1038/s41592-022-01760-4.

Abstract

Dramatic advances in protein structure prediction have sparked debate as to whether the problem of predicting structure from sequence is solved or not. Here, I argue that AlphaFold2 and its peers are currently limited by the fact that they predict only a single structure, instead of a structural distribution, and that this realization is crucial for the next generation of structure prediction algorithms.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Protein Conformation*
  • Proteins*

Substances

  • Proteins