A sonochemical synthesis of SrTiO3 supported N-doped graphene oxide as a highly efficient electrocatalyst for electrochemical reduction of a chemotherapeutic drug

Umamaheswari Rajaji; M S Raghu; K Yogesh Kumar; Tahani M Almutairi; AbdallahA A Mohammed; Ruey-Shin Juang; Ting-Yu Liu

doi:10.1016/j.ultsonch.2023.106293

A sonochemical synthesis of SrTiO₃ supported N-doped graphene oxide as a highly efficient electrocatalyst for electrochemical reduction of a chemotherapeutic drug

Ultrason Sonochem. 2023 Feb:93:106293. doi: 10.1016/j.ultsonch.2023.106293. Epub 2023 Jan 7.

Authors

Umamaheswari Rajaji¹, M S Raghu², K Yogesh Kumar³, Tahani M Almutairi⁴, AbdallahA A Mohammed⁴, Ruey-Shin Juang⁵, Ting-Yu Liu⁶

Affiliations

¹ Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan.
² Department of Chemistry, New Horizon College of Engineering, Outer Ring Road, Bangalore 560103, India.
³ Department of Chemistry, Faculty of Engineering and Technology, Jain University, Bangalore 562112, India; Korea University of Technology and Education, Cheonan-si 31253, Chungcheongnam-do, Cheonan-si, Republic of Korea.
⁴ Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
⁵ Department of Chemical and Materials Engineering, Chang Gung University 259 Wenhua First Road Guishan, Taoyuan 33302, Taiwan; Division of Nephrology, Department of Internal Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan; Department of Safety, Health and Environmental Engineering, Ming Chi University of Technology, Taishan, New Taipei City 243303, Taiwan. Electronic address: rsjuang@mail.cgu.edu.tw.
⁶ Department of Materials Engineering, Ming Chi University of Technology, New Taipei City 243303, Taiwan; Research Center for Intelligent Medical Devices, Center for Plasma and Thin Film Technologies, Ming Chi University of Technology, New Taipei City 243303, Taiwan. Electronic address: tyliu0322@gmail.com.

Abstract

A sonochemical based green synthesis method playa powerful role in nanomaterials and composite development. In this work, we developed a perovskite type of strontium titanate via sonochemical process. SrTiO₃ particles were incorporated with nitrogen doped graphene oxide through simple ultrasonic irradiation method. The SrTiO₃/NGO was characterized by various analytical methods. The nanocomposite of SrTiO₃/NGO was modified with laser-induced graphene electrode (LIGE). The SrTiO₃/NGO/LIGE was applied for electrochemical sensor towards chemotherapeutic drug detection (nilutamide). Cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques have been used to examine the electrochemical performance of nilutamide (anti-cancer drug). DPV was found to be more sensitive and found to exhibit a sensitivity 8.627 µA µM^-1 cm^-2 for SrTiO₃/NGO/LIGE with a wide linear range (0.02-892 µM) and low Limit of detection (LOD: 1.16 µM). SrTiO₃/NGO/LIGE has been examined for the detection of nilutamide in blood serum and urine samples and obtained a good recovery in the range of 97.2-99.72 %. The enhanced stability and selectivity and practical application results indicates the suitability of SrTiO₃/NGO/LIGE towards the detection of nilutamide drug in pharmaceutical industries.

Keywords: Biological fluids analysis; Laser-induced graphene electrode; N doped graphene oxide; Nilutamide drug; Sonochemical synthesis; Strontium titanate.

MeSH terms

Antineoplastic Agents*
Electrochemical Techniques / methods
Electrodes
Graphite* / chemistry

Substances

graphene oxide
Graphite
Antineoplastic Agents