3D-Printed scaffolds based on poly(Trimethylene carbonate), poly(ε-Caprolactone), and β-Tricalcium phosphate

Si-Yao Zheng; Zhi-Wei Liu; Hong-Lei Kang; Fan Liu; Guo-Ping Yan; Feng Li

doi:10.18063/ijb.v9i1.641

3D-Printed scaffolds based on poly(Trimethylene carbonate), poly(ε-Caprolactone), and β-Tricalcium phosphate

Int J Bioprint. 2022 Nov 14;9(1):641. doi: 10.18063/ijb.v9i1.641. eCollection 2023.

Authors

Si-Yao Zheng¹, Zhi-Wei Liu¹, Hong-Lei Kang², Fan Liu¹, Guo-Ping Yan¹, Feng Li²

Affiliations

¹ School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan 430 205, China.
² Department of Orthopaedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430 022, China.

Abstract

Three-dimensional (3D)-printed scaffolds of biodegradable polymers have been increasingly applied in bone repair and regeneration, which helps avoid the second surgery. PTMC/PCL/TCP composites were made using poly(trimethylene carbonate), poly(ε-caprolactone), and β-tricalcium phosphate. PTMC/PCL/TCP scaffolds were manufactured using a biological 3D printing technique. Furthermore, the properties of PTMC/PCL/TCP scaffolds, such as biodegradation, mechanic properties, drug release, cell cytotoxicity, cell proliferation, and bone repairing capacity, were evaluated. We showed that PTMC/PCL/TCP scaffolds had low cytotoxicity and good biocompatibility, and they also enhanced the proliferation of osteoblast MC3T3-E1 and rBMSC cell lines, which demonstrated improved adhesion, penetration, and proliferation. Moreover, PTMC/PCL/TCP scaffolds can enhance bone induction and regeneration, indicating that they can be used to repair bone defects in vivo.

Keywords: Biodegradability; Bone regeneration; Cell proliferation; Poly(trimethylene carbonate); Poly(ε-caprolactone); β-tricalcium phosphate.