Finger doses due to68Ga-labelled pharmaceuticals in PET departments-results of a multi-centre pilot study

J Radiol Prot. 2023 Feb 1;43(1). doi: 10.1088/1361-6498/acb263.

Abstract

Introduction: Although the use of68Ga has increased substantially in nuclear medicine over the last decade, there is limited information available on occupational exposure due to68Ga. The purpose of this study is to determine the occupational extremity exposure during the preparation, dispensing and administration of68Ga-labelled radiopharmaceuticals.

Method: Workers in eight centres wore a ring dosimeter for all tasks involving68Ga-labelled radiopharmaceuticals for a minimum of one month. Additionally, the fingertip dose was monitored in two centres and the hand with the highest ring dose during68Ga procedures was also identified in one centre.

Results: The median normalised ring dose for68Ga procedures was found to be 0.25 mSv GBq-1(range 0.01-3.34). The normalised68Ga ring doses recorded in this study are similar to that found in the literature for18F. This study is consistent with previous findings that the highest extremity dose is found on the non-dominant hand. A limited sub study in two of the centres showed a median fingertip to base of the finger dose ratio of 4.3. Based on this median ratio, the extrapolated annual68Ga fingertip dose for 94% of the workers monitored in this study would be below Category B dose limit (150 mSv) and no worker would exceed Category A dose limit (500 mSv).

Conclusion: When appropriate shielding and radiation protection practices are employed, the extremity dose due to68Ga is comparable to that of18F and is expected to be well below the regulatory limits for the majority of workers.

Keywords: 68Ga; Hp(0.07); extremity dose; occupational exposure.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Fingers
  • Humans
  • Occupational Exposure* / analysis
  • Pharmaceutical Preparations
  • Pilot Projects
  • Positron-Emission Tomography
  • Radiation Dosage
  • Radiopharmaceuticals*

Substances

  • Radiopharmaceuticals
  • Pharmaceutical Preparations