Bacteria-based bioactive materials for cancer imaging and therapy

Ying Chen; Zi-Hao Li; Xuan Zeng; Xian-Zheng Zhang

doi:10.1016/j.addr.2023.114696

Bacteria-based bioactive materials for cancer imaging and therapy

Adv Drug Deliv Rev. 2023 Feb:193:114696. doi: 10.1016/j.addr.2023.114696. Epub 2023 Jan 9.

Authors

Ying Chen¹, Zi-Hao Li¹, Xuan Zeng¹, Xian-Zheng Zhang²

Affiliations

¹ Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
² Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, PR China; Wuhan Research Centre for Infectious Diseases and Cancer, Chinese Academy of Medical Sciences, Wuhan 430071, PR China. Electronic address: xz-zhang@whu.edu.cn.

PMID: 36632868
DOI: 10.1016/j.addr.2023.114696

Abstract

Owing to the unique biological functions, bacteria as biological materials have been widely used in biomedical field. With advances in biotechnology and nanotechnology, various bacteria-based bioactive materials were developed for cancer imaging and therapy. In this review, different types of bacteria-based bioactive materials and their construction strategies were summarized. The advantages and property-function relationship of bacteria-based bioactive materials were described. Representative researches of bacteria-based bioactive materials in cancer imaging and therapy were illustrated, revealing general ideas for their construction. Also, limitation and challenges of bacteria-based bioactive materials in cancer research were discussed.

Keywords: Bacteria; Bioactive material; Biohybrid; Cancer imaging; Cancer therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bacteria
Diagnostic Imaging
Humans
Nanotechnology* / methods
Neoplasms*