Portal vein thrombosis as the presenting manifestation of JAK2 positive myeloproliferative neoplasm

Am J Med Sci. 2023 May;365(5):457-461. doi: 10.1016/j.amjms.2023.01.002. Epub 2023 Jan 9.

Abstract

Deep venous thrombosis (DVT) is a complication of myeloproliferative neoplasms (MPNs). However, DVTs in unusual sites such as portal vein thrombosis (PVT) are rare and may be the first clinical manifestation of occult MPNs. There is a need for increasing awareness of such manifestations; so, here we discuss a patient who presented with new portal vein thrombosis, underwent further studies, was ultimately diagnosed with JAK2 positive MPN, and started on appropriate treatment with improvement of thrombosis and controlled hematocrit.

Keywords: Deep vein thrombosis; JAK2; Myeloproliferative neoplasms; Philadelphia chromosome; Polycythemia vera.

Publication types

  • Review

MeSH terms

  • Bone Marrow Neoplasms*
  • Humans
  • Janus Kinase 2 / genetics
  • Liver Diseases*
  • Mutation
  • Myeloproliferative Disorders* / complications
  • Myeloproliferative Disorders* / diagnosis
  • Portal Vein / diagnostic imaging
  • Thrombosis* / etiology
  • Venous Thrombosis* / diagnostic imaging
  • Venous Thrombosis* / drug therapy
  • Venous Thrombosis* / etiology

Substances

  • Janus Kinase 2
  • JAK2 protein, human