Human Immunodeficiency Virus Type 1 RNA Genital Tract Shedding After Cryotherapy for Cervical Intraepithelial Neoplasia in Western Kenya

Elkanah Omenge Orang'o; Anne E Bocage; Tao D Liu; Peter M Itsura; Philip K Tonui; Kapten Muthoka; Kiptoo Stephen; Angela M Caliendo; Soya S Sam; Susan Cu-Uvin

doi:10.1093/ofid/ofac662

Human Immunodeficiency Virus Type 1 RNA Genital Tract Shedding After Cryotherapy for Cervical Intraepithelial Neoplasia in Western Kenya

Open Forum Infect Dis. 2022 Dec 16;10(1):ofac662. doi: 10.1093/ofid/ofac662. eCollection 2023 Jan.

Authors

Affiliations

¹ Department of Reproductive Health, Moi University, Eldoret, Kenya.
² Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
³ Department of Biostatistics, Brown University, Providence, Rhode Island, USA.
⁴ Academic Model Providing Access to Healthcare Partnership, Eldoret, Kenya.
⁵ Division of Infectious Disease, The Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
⁶ Division of Infectious Diseases, Miriam Hospital, Providence, Rhode Island, USA.

Abstract

This prospective study of 39 women living with human immunodeficiency virus (HIV) on antiretroviral therapy in Western Kenya aimed to quantify genital tract HIV-1 RNA (GT-HIV RNA) shedding before and after cryotherapy for cervical intraepithelial neoplasia. Most GT-HIV RNA shedding was detected precryotherapy, suggesting that cryotherapy was not the primary cause of shedding.

Keywords: HIV; HIV genital tract viral load; Kenya; cervical cancer; cervical cancer treatment; cryotherapy.